Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 6/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.43 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.43 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.43 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.43 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.42 |
| ▸ | HTR3B | O95264 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.42 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535785 | 0.90 | SLC6A9 (0.58) | SLC6A9TP53MAPTLMNAENPP2 | |
| SCHEMBL9537811 | 0.89 | SLC6A9 (0.60) | SLC6A9TP53MAPTLMNAENPP2 | |
| SCHEMBL9540167 | 0.88 | SLC6A9 (0.56) | SLC6A9TP53MAPTLMNAENPP2 | |
| SCHEMBL9535367 | 0.88 | SLC6A9 (0.58) | SLC6A9TP53MAPTLMNAENPP2 | |
| SCHEMBL9535970 | 0.87 | SLC6A9 (0.55) | SLC6A9TP53MAPTLMNAENPP2 | |
| SCHEMBL10547724 | 0.87 | SLC6A9 (0.55) | SLC6A9TP53MAPTLMNAENPP2 | |
| SCHEMBL9535415 | 0.87 | SLC6A9 (0.55) | SLC6A9TP53MAPTLMNAENPP2 | |
| SCHEMBL9538693 | 0.86 | SLC6A9 (0.52) | SLC6A9TP53MAPTLMNAENPP2 | |
| SCHEMBL9537582 | 0.86 | TP53 (0.53) | SLC6A9TP53MAPTLMNAENPP2 | |
| SCHEMBL9535114 | 0.86 | SLC6A9 (0.53) | SLC6A9TP53MAPTLMNAENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |