Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | CRHBP | P24387 | 2/20 | 0.54 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10549767 | 0.89 | ALDH1A1 (0.49) | ALDH1A1TDP1MAPTL3MBTL1MEN1 | |
| SCHEMBL10842868 | 0.83 | MAPT (0.60) | ALDH1A1MAPTL3MBTL1MEN1KMT2A | |
| SCHEMBL14249377 | 0.82 | ALDH1A1 (0.57) | ALDH1A1TDP1MAPTL3MBTL1MEN1 | |
| SCHEMBL6930910 | 0.81 | ALDH1A1 (0.62) | ALDH1A1TDP1MAPTL3MBTL1MEN1 | |
| SCHEMBL22519987 | 0.79 | MAPT (0.50) | ALDH1A1TDP1MAPTL3MBTL1MEN1 | |
| SCHEMBL9537223 | 0.79 | MAPT (0.58) | ALDH1A1MAPTL3MBTL1MEN1KMT2A | |
| SCHEMBL5157517 | 0.79 | ALDH1A1 (0.53) | ALDH1A1TDP1MAPTL3MBTL1KMT2A | |
| SCHEMBL2498853 | 0.79 | ALDH1A1 (0.53) | ALDH1A1TDP1MAPTL3MBTL1MEN1 | |
| SCHEMBL30418372 | 0.79 | MEN1 (0.56) | ALDH1A1TDP1MAPTL3MBTL1MEN1 | |
| SCHEMBL9537129 | 0.78 | MAPT (0.60) | ALDH1A1TDP1MAPTL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |