SCHEMBL9537281

SCHEMBL9537281

COc1nc(Cl)n2nc(S(=O)(=O)Nc3c(Cl)cccc3Cl)nc2c1Br

nearest known ligand 0.48

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
CCR4 P51679 14/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9536181 0.91 CCR4 (0.42) CCR4
SCHEMBL9534479 0.87 SMN1; SMN2 (0.34) CCR4
SCHEMBL8825653 0.81 CCR4 (0.46) CCR4
SCHEMBL9535406 0.80 CCR4 (0.44) CCR4
SCHEMBL9536906 0.79 SMN1; SMN2 (0.34) CCR4
SCHEMBL8555883 0.78 ALDH1A1 (0.30)
SCHEMBL8825643 0.78 CCR4 (0.43) CCR4
SCHEMBL8556082 0.77 CCR4 (0.41) CCR4
SCHEMBL8825636 0.75 CCR4 (0.42) CCR4
SCHEMBL9536404 0.75 CCR4 (0.38) CCR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0343752-B1 Alkoxy-1,2,4-triazolo (1,5-c) pyrimidine-2-sulfonamides, process for their preparation and intermediates DOWELANCO (US) 1993-12-01 EP disclosed
US-5163995-A For use with grassy crops and soybeans DOWELANCO (US) 1992-11-17 US disclosed
US-5010195-A From 5-alkoxy-1,2,4-triazolo(1,5-c)pyrimidine THE DOW CHEMICAL COMPANY (US) 1991-04-23 US disclosed
WO-1989011782-A1 ALKOXY-1,2,4-TRIAZOLO[1,5-c]PYRIMIDINE-2-SULFONAMIDES, PROCESS FOR THEIR PREPARATION AND INTERMEDIATES THE DOW CHEMICAL COMPANY (US) 1989-12-14 WO disclosed
EP-0343752-A1 Alkoxy-1,2,4-triazolo (1,5-c) pyrimidine-2-sulfonamides, process for their preparation and intermediates DowElanco (US) 1989-11-29 EP disclosed