Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9537334 | 1.00 | ENPP2 (0.44) | ENPP2HPGDMAPTTP53LMNA | |
| SCHEMBL9537238 | 0.95 | KCNH2 (0.43) | ENPP2HPGDMAPTLMNAHTT | |
| Oxalic Acid SCHEMBL9540171 | 0.90 | ENPP2 (0.44) | ENPP2HPGDMAPTTP53LMNA | |
| Oxalic Acid SCHEMBL9540168 | 0.90 | ENPP2 (0.44) | ENPP2HPGDMAPTTP53LMNA | |
| Oxalic Acid SCHEMBL10802671 | 0.87 | GRIN2B (0.41) | TP53LMNASMN1; SMN2SLC6A9GRIN2B | |
| Oxalic Acid SCHEMBL9538513 | 0.87 | GRIN2B (0.41) | TP53LMNASMN1; SMN2SLC6A9GRIN2B | |
| Oxalic Acid SCHEMBL9538518 | 0.87 | GRIN2B (0.41) | TP53LMNASMN1; SMN2SLC6A9GRIN2B | |
| SCHEMBL9536807 | 0.86 | SSTR5 (0.50) | MAPTTP53LMNAHTTSMN1; SMN2 | |
| Oxalic Acid SCHEMBL9537142 | 0.84 | HPGD (0.43) | ENPP2HPGDMAPTTP53LMNA | |
| Oxalic Acid SCHEMBL9537131 | 0.84 | HPGD (0.43) | ENPP2HPGDMAPTTP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |