Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | CCR3 | P51677 | 4/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL10802671 | 1.00 | GRIN2B (0.41) | GRIN2BCCR3SLC6A9OPRK1KDM4E | |
| Oxalic Acid SCHEMBL9538518 | 1.00 | GRIN2B (0.41) | GRIN2BCCR3SLC6A9OPRK1KDM4E | |
| SCHEMBL9537882 | 0.95 | SLC6A9 (0.41) | GRIN2BSLC6A9SSTR5 | |
| Oxalic Acid SCHEMBL9537334 | 0.87 | ENPP2 (0.44) | GRIN2BSLC6A9SMN1; SMN2KDM1AHDAC6 | |
| Oxalic Acid SCHEMBL9537337 | 0.87 | ENPP2 (0.44) | GRIN2BSLC6A9SMN1; SMN2KDM1AHDAC6 | |
| SCHEMBL9536807 | 0.85 | SSTR5 (0.50) | OPRK1SMN1; SMN2SSTR5LMNAMEN1 | |
| Oxalic Acid SCHEMBL10546958 | 0.83 | HRH1 (0.57) | OPRK1SMN1; SMN2SSTR5LMNAMEN1 | |
| SCHEMBL9537190 | 0.82 | PRMT3 (0.44) | SLC6A9SSTR5 | |
| SCHEMBL9536547 | 0.82 | SSTR5 (0.52) | CCR3SSTR5 | |
| SCHEMBL9535415 | 0.82 | SLC6A9 (0.55) | SLC6A9LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |