Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | CCR3 | P51677 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9537131 | 1.00 | HPGD (0.43) | HPGDSLC6A2SLC6A4TP53LMNA | |
| SCHEMBL10547215 | 0.90 | POLB (0.49) | SLC6A2SLC6A4CCR3POLB | |
| SCHEMBL10549253 | 0.84 | CCR3 (0.52) | CCR3POLB | |
| SCHEMBL10552594 | 0.84 | LMNA (0.54) | TP53LMNAMAPTENPP2THRB | |
| Oxalic Acid SCHEMBL9537337 | 0.84 | ENPP2 (0.44) | HPGDTP53LMNAMAPTENPP2 | |
| Oxalic Acid SCHEMBL9537334 | 0.84 | ENPP2 (0.44) | HPGDTP53LMNAMAPTENPP2 | |
| SCHEMBL9544455 | 0.82 | POLB (0.52) | SLC6A2SLC6A4TP53LMNAMAPT | |
| SCHEMBL9536266 | 0.82 | OPRK1 (0.51) | SLC6A2SLC6A4TP53POLB | |
| Oxalic Acid SCHEMBL9540168 | 0.81 | ENPP2 (0.44) | HPGDTP53LMNAMAPTENPP2 | |
| Oxalic Acid SCHEMBL9540171 | 0.81 | ENPP2 (0.44) | HPGDTP53LMNAMAPTENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |