Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | F7 | P08709 | 1/20 | 0.34 |
| ▸ | F3 | P13726 | 1/20 | 0.34 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9301523 | 0.85 | TDP1 (0.40) | TDP1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL9539358 | 0.74 | CYP3A4 (0.48) | TDP1LMNACYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL8865984 | 0.70 | ALDH1A1 (0.58) | TDP1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL9537381 | 0.68 | ALOX5 (0.53) | CYP1A2CYP11B1CYP11B2RAB9ASMN1; SMN2 | |
| SCHEMBL9304107 | 0.67 | KMT2A (0.37) | TDP1LMNAALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL800783 | 0.67 | LMNA (0.51) | TDP1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL9431575 | 0.66 | GLRA3 (0.32) | — | |
| SCHEMBL9405525 | 0.65 | BAZ2B (0.31) | — | |
| SCHEMBL29721526 | 0.65 | ALDH1A1 (0.57) | TDP1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL9412699 | 0.65 | ALDH1A1 (0.57) | TDP1LMNACYP1A2CYP3A4CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0569491-A4 | 2-SUBSTITUTED-4,6-DI-TERTIARY-BUTYL-5-HYDROXY-1,3-PYRIMIDINES USEFUL AS ANTIINFLAMMATORY AGENTS | — | 1993-11-24 | — | — | EP | claimed |