Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | PYGM | P11217 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GALR3 | O60755 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9540292 | 0.87 | SLC6A9 (0.62) | SLC6A9MAPTALDH1A1SLC6A2SLC6A4 | |
| SCHEMBL9539993 | 0.86 | MEN1 (0.48) | ALDH1A1LMNASLC6A2SLC6A4 | |
| SCHEMBL9536175 | 0.86 | SLC6A2 (0.48) | SLC6A9MAPTALDH1A1SLC6A2SLC6A4 | |
| SCHEMBL10549281 | 0.85 | SLC6A9 (0.43) | SLC6A9HPGDSMN1; SMN2KDM4EMAPT | |
| SCHEMBL9535187 | 0.84 | ALDH1A1 (0.45) | HPGDSMN1; SMN2KDM4EMAPTTSHR | |
| SCHEMBL10798752 | 0.84 | SLC6A9 (0.41) | SLC6A9HPGDSMN1; SMN2KDM4EMAPT | |
| SCHEMBL9536524 | 0.83 | MEN1 (0.47) | SMN1; SMN2MAPTLMNASLC6A2SLC6A4 | |
| SCHEMBL9537145 | 0.83 | SLC6A9 (0.53) | SLC6A9HPGDSMN1; SMN2KDM4EMAPT | |
| SCHEMBL9536956 | 0.83 | KCNH2 (0.49) | SMN1; SMN2MAPTLMNASLC6A2SLC6A4 | |
| SCHEMBL9689139 | 0.81 | EED (0.47) | HPGDSMN1; SMN2KDM4EMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |