Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9538015 | 0.89 | SLC6A9 (0.65) | SLC6A9TSHRMAPTHSD17B10GRIN2B | |
| SCHEMBL9538238 | 0.86 | MEN1 (0.49) | HTTGRIN2BNPSR1TDP1MEN1 | |
| SCHEMBL9536155 | 0.84 | USP2 (0.42) | SLC6A9SMN1; SMN2TSHRKDM4EMAPT | |
| SCHEMBL9537428 | 0.83 | SLC6A9 (0.46) | SLC6A9SMN1; SMN2TSHRKDM4EMAPT | |
| SCHEMBL9539219 | 0.83 | HRH1 (0.42) | SLC6A9KDM4EMKNK1HRH1HTT | |
| SCHEMBL9536807 | 0.83 | SSTR5 (0.50) | SMN1; SMN2MAPTHRH1HTTRAB9A | |
| SCHEMBL9536207 | 0.82 | SLC6A9 (0.43) | SLC6A9SMN1; SMN2TSHRKDM4EMAPT | |
| SCHEMBL8565529 | 0.82 | GRIN2B (0.38) | SLC6A9KDM4EHPGDHSD17B10MKNK1 | |
| SCHEMBL9536175 | 0.82 | SLC6A2 (0.48) | SLC6A9MAPTMEN1KMT2A | |
| SCHEMBL9539084 | 0.81 | MEN1 (0.52) | SLC6A9SMN1; SMN2TSHRKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | claimed |