Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 2/20 | 0.49 |
| ▸ | PLD2 | O14939 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 2/20 | 0.48 |
| ▸ | TACR2 | P21452 | 1/20 | 0.48 |
| ▸ | TACR1 | P25103 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CCR3 | P51677 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10546904 | 0.89 | HRH1 (0.46) | SSTR5MAPTHRH1TACR2TACR1 | |
| SCHEMBL9536186 | 0.84 | MAPT (0.56) | SSTR5MAPTTP53CHRM4CCR3 | |
| SCHEMBL9536075 | 0.84 | HRH1 (0.62) | SSTR5MAPTHRH1TACR2TACR1 | |
| SCHEMBL11485440 | 0.81 | SSTR5 (0.70) | SSTR5MAPTHRH1TACR2TACR1 | |
| SCHEMBL9536636 | 0.78 | CCR3 (0.65) | MAPTTP53KCNH2CCR3 | |
| SCHEMBL9536278 | 0.78 | SSTR5 (0.49) | SSTR5MAPTHRH1TACR2TACR1 | |
| SCHEMBL9535563 | 0.77 | TP53 (0.51) | HRH1TACR2TACR1TP53KCNH2 | |
| SCHEMBL9537124 | 0.76 | LMNA (0.48) | SSTR5HRH1TACR2TACR1KCNH2 | |
| SCHEMBL10550542 | 0.75 | SLC18A2 (0.55) | SSTR5MAPTHRH1TP53KCNH2 | |
| Oxalic Acid SCHEMBL9538011 | 0.75 | PLD2 (0.47) | SSTR5PLD2MAPTTP53KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |