Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.34 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 10/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 10/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 8/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 8/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 8/20 | 0.34 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | PTGES | O14684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2625552 | 0.78 | — | — | |
| SCHEMBL7455219 | 0.72 | F2RL1 (0.40) | KCNA5KCNE1ADRA2AADRA2CALOX15 | |
| SCHEMBL22827208 | 0.71 | — | — | |
| SCHEMBL25760621 | 0.71 | FDPS (0.50) | FDPSADRA2AADRA2CADRA1DADRA1A | |
| SCHEMBL15720305 | 0.69 | ADRA2A (0.41) | FDPSADRA2AADRA2CADRA1DADRA1A | |
| SCHEMBL9539151 | 0.69 | ALDH1A1 (0.48) | FDPSKCNA5KCNE1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3558974 | 0.68 | F2RL1 (0.41) | KCNA5KCNE1ALOX15KCNH2HRH3 | |
| SCHEMBL2638056 | 0.66 | FDPS (0.53) | FDPSADRA2AADRA2CADRA1DADRA1A | |
| SCHEMBL11103701 | 0.66 | FDPS (0.53) | FDPSADRA2AADRA2CADRA1DADRA1A | |
| SCHEMBL2638054 | 0.66 | FDPS (0.53) | FDPSADRA2AADRA2CADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | claimed |