Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9537980 | 0.81 | SIGMAR1 (0.47) | SIGMAR1TSHRRECQLALDH1A1SMN1; SMN2 | |
| SCHEMBL9060155 | 0.75 | PTGS2 (0.54) | SIGMAR1PTGS2MEN1KMT2AALOX5 | |
| SCHEMBL9061357 | 0.74 | SIGMAR1 (0.60) | SIGMAR1TSHRRECQLALDH1A1SMN1; SMN2 | |
| SCHEMBL9059154 | 0.70 | POLB (0.40) | SIGMAR1SMN1; SMN2KDM4ELMNAKMT2A | |
| SCHEMBL9537649 | 0.69 | POLB (0.39) | SIGMAR1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL9061389 | 0.68 | SIGMAR1 (0.39) | SIGMAR1ALDH1A1MEN1KMT2A | |
| Iodide SCHEMBL10827362 | 0.68 | SIGMAR1 (0.55) | SIGMAR1HTTKDM4EMEN1LMNA | |
| SCHEMBL8518311 | 0.68 | SIGMAR1 (0.54) | SIGMAR1HTTKDM4EMEN1LMNA | |
| Hydrochloric Acid SCHEMBL28106772 | 0.68 | TSHR (0.54) | TSHRRECQLALDH1A1SMN1; SMN2HTT | |
| SCHEMBL11485191 | 0.67 | SIGMAR1 (0.50) | SIGMAR1ALDH1A1HTTKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0536151-A1 | ORTHOSUBSTITUTED BIPHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM. | BOOTS CO PLC (GB) | 1993-04-14 | — | — | EP | disclosed |