Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 10/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 14/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9369331 | 0.78 | LMNA (0.55) | S1PR1S1PR3GAANPSR1TSHR | |
| SCHEMBL30503691 | 0.72 | MTOR (0.48) | S1PR1TSHRHSD11B1 | |
| SCHEMBL29024940 | 0.72 | MTOR (0.48) | S1PR1TSHRHSD11B1 | |
| SCHEMBL9537139 | 0.71 | LMNA (0.48) | S1PR1S1PR3GAANPSR1TSHR | |
| SCHEMBL18979742 | 0.71 | P4HTM (0.47) | TSHRLMNAKDM4EMEN1ALOX15 | |
| SCHEMBL29289785 | 0.70 | S1PR3 (0.55) | S1PR1S1PR3GAAKDM4E | |
| SCHEMBL31098649 | 0.70 | S1PR3 (0.55) | S1PR1S1PR3GAAKDM4E | |
| SCHEMBL7995510 | 0.70 | P4HTM (0.46) | TSHRLMNAKDM4EMEN1ALOX15 | |
| SCHEMBL28824869 | 0.69 | S1PR1 (0.39) | S1PR1LMNAMEN1KMT2A | |
| SCHEMBL9812799 | 0.67 | HSD11B1 (0.58) | S1PR1S1PR3GAANPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0417745-B1 | Heteroaryl substituted imidazo [4,5-c] pyridines | SEARLE & CO (US) | 1993-11-03 | — | — | EP | disclosed |
| EP-0417745-A2 | Heteroaryl substituted imidazo [4,5-c] pyridines | G.D. Searle & Co. (US) | 1991-03-20 | — | — | EP | disclosed |
| US-4990518-A | Platelet activating factor | G. D. SEARLE & CO. (US) | 1991-02-05 | — | — | US | disclosed |