Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 5/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9536415 | 0.90 | KDM4E (0.48) | KDM4EMAPTMEN1KMT2AHPGD | |
| SCHEMBL9538894 | 0.87 | SLC6A9 (0.44) | KDM4EMAPTMEN1KMT2AHPGD | |
| Barmastine SCHEMBL141926 | 0.86 | KDM4E (0.45) | KDM4EMAPTMEN1KMT2AHPGD | |
| Barmastine SCHEMBL30712053 | 0.86 | KDM4E (0.45) | KDM4EMAPTMEN1KMT2AHPGD | |
| SCHEMBL9537351 | 0.86 | HTR1A (0.56) | KDM4EMAPTMEN1KMT2AHPGD | |
| SCHEMBL9535132 | 0.84 | SLC6A9 (0.43) | MAPTHTR1ATSHRDRD2HTR2A | |
| SCHEMBL9536136 | 0.83 | SLC6A9 (0.44) | KDM4EHPGDHTR1ATSHRDRD2 | |
| Hydrochloric Acid SCHEMBL9535191 | 0.82 | SLC6A9 (0.43) | KDM4EHPGDHTR1ATSHRDRD2 | |
| SCHEMBL9538129 | 0.80 | GAA (0.51) | KDM4EMAPTHTR1ATSHRSMN1; SMN2 | |
| SCHEMBL9537181 | 0.78 | SLC6A9 (0.49) | KDM4EMAPTMEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | claimed |