Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 9/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9537429 | 0.89 | GAA (0.52) | GAATSHRALDH1A1MAPK1NPSR1 | |
| SCHEMBL9535214 | 0.86 | SLC6A9 (0.41) | GAATSHRALDH1A1MAPK1NPSR1 | |
| SCHEMBL9540573 | 0.85 | SLC6A9 (0.52) | GAAALDH1A1SLC6A9LMNAHTR1A | |
| SCHEMBL9539651 | 0.85 | ALDH1A1 (0.47) | TSHRALDH1A1SMN1; SMN2HSD17B10ALOX15 | |
| SCHEMBL9537181 | 0.82 | SLC6A9 (0.49) | GAATSHRALDH1A1MAPK1NPSR1 | |
| SCHEMBL9537207 | 0.82 | SLC6A9 (0.47) | TSHRALDH1A1MAPK1NPSR1SLC6A9 | |
| Water SCHEMBL10554595 | 0.82 | SLC6A9 (0.41) | GAATSHRALDH1A1MAPK1NPSR1 | |
| SCHEMBL9540587 | 0.82 | TSHR (0.50) | GAATSHRALDH1A1MAPK1NPSR1 | |
| SCHEMBL10550979 | 0.82 | TSHR (0.50) | GAATSHRALDH1A1MAPK1NPSR1 | |
| SCHEMBL10549053 | 0.81 | HSD17B10 (0.42) | GAATSHRALDH1A1MAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |