Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ENPP2 | Q13822 | 6/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9538447 | 0.89 | GAA (0.52) | GAATP53MAPTLMNAHTR1A | |
| SCHEMBL9537494 | 0.86 | SLC6A9 (0.48) | SLC6A9ENPP2TP53MAPTLMNA | |
| SCHEMBL9536214 | 0.86 | SLC18A2 (0.53) | SLC6A9ENPP2TP53MAPTLMNA | |
| SCHEMBL9538129 | 0.85 | GAA (0.51) | SLC6A9GAAMAPTLMNAHTR1A | |
| SCHEMBL9536553 | 0.84 | HTR2A (0.54) | SLC6A9ENPP2MAPTLMNAHTR1A | |
| SCHEMBL9535367 | 0.83 | SLC6A9 (0.58) | SLC6A9ENPP2TP53MAPTLMNA | |
| SCHEMBL9537811 | 0.83 | SLC6A9 (0.60) | SLC6A9GAAENPP2TP53MAPT | |
| SCHEMBL9537085 | 0.82 | SLC6A9 (0.58) | SLC6A9ENPP2TP53MAPTLMNA | |
| SCHEMBL9535785 | 0.82 | SLC6A9 (0.58) | SLC6A9ENPP2TP53MAPTLMNA | |
| SCHEMBL9535970 | 0.81 | SLC6A9 (0.55) | SLC6A9ENPP2TP53MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |