Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | PER2 | O15055 | 1/20 | 0.37 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.37 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 9/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 5/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9536376 | 0.87 | KDM4E (0.41) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL9538092 | 0.83 | PER2 (0.35) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL9538345 | 0.78 | RORC (0.38) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL9538335 | 0.71 | SLC2A1 (0.46) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL9537180 | 0.70 | RORC (0.35) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL9537944 | 0.69 | ALDH1A1 (0.38) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL9536368 | 0.68 | MAPT (0.41) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL9538002 | 0.67 | KDM4E (0.48) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL9779030 | 0.66 | MAPT (0.53) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL11154440 | 0.65 | MAPT (0.62) | MAPTMEN1KMT2AALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0182608-B1 | POLYCYCLIC COMPOUNDS, THEIR PREPARATION AND FORMULATIONS CONTAINING THEM | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-03-03 | — | — | EP | disclosed |
| EP-0182608-A2 | Polycyclic compounds, their preparation and formulations containing them | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-05-28 | — | — | EP | disclosed |