Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535341 | 0.90 | GPBAR1 (0.54) | GPBAR1MAPTHSD17B10TP53SMN1; SMN2 | |
| SCHEMBL9533421 | 0.86 | SCN9A (0.49) | GPBAR1MAPTALDH1A1POLBTSHR | |
| SCHEMBL9532926 | 0.83 | PTGS1 (0.54) | GPBAR1POLBCYP2C19TSHR | |
| SCHEMBL9533615 | 0.83 | HSD17B10 (0.59) | GPBAR1MAPTHSD17B10TP53SMN1; SMN2 | |
| SCHEMBL9536053 | 0.81 | SCN9A (0.53) | GPBAR1MAPTTP53SMN1; SMN2HPGD | |
| SCHEMBL9535705 | 0.79 | GPBAR1 (0.48) | GPBAR1SMN1; SMN2CYP2C19 | |
| SCHEMBL9535220 | 0.76 | GHSR (0.51) | GPBAR1MAPTALDH1A1POLBTSHR | |
| SCHEMBL5243618 | 0.72 | HSD17B10 (0.59) | GPBAR1MAPTHSD17B10TP53SMN1; SMN2 | |
| SCHEMBL27936754 | 0.72 | HSD17B10 (0.59) | GPBAR1MAPTHSD17B10TP53SMN1; SMN2 | |
| SCHEMBL16697481 | 0.72 | HSD17B10 (0.52) | GPBAR1MAPTHSD17B10HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0573883-A1 | Utilization of 3 substituted aryl-5-alkyl-isoxazole-4-carboxylic acid derivatives against endoparasites new 3-substituted aryl-5-alkyl-isoxazole-4-carboxylic acid derivatives and process for their preparation | BAYER AG (DE) | 1993-12-15 | — | — | EP | disclosed |