Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 14/20 | 0.69 |
| ▸ | NPC1 | O15118 | 12/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.57 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.57 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 5/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14864884 | 0.83 | RAB9A (0.56) | RAB9ANPC1SMN1; SMN2CYP1A2LMNA | |
| SCHEMBL2807153 | 0.81 | RAB9A (1.00) | RAB9ANPC1SMN1; SMN2CYP1A2LMNA | |
| SCHEMBL9868697 | 0.78 | RAB9A (0.76) | RAB9ANPC1SMN1; SMN2CYP1A2POLB | |
| SCHEMBL7059292 | 0.78 | SMN1; SMN2 (0.60) | RAB9ANPC1SMN1; SMN2CYP1A2LMNA | |
| SCHEMBL3975040 | 0.77 | RAB9A (0.78) | RAB9ANPC1SMN1; SMN2LMNAPOLB | |
| SCHEMBL18640751 | 0.77 | RAB9A (0.57) | RAB9ANPC1SMN1; SMN2CYP1A2LMNA | |
| SCHEMBL421493 | 0.76 | RAB9A (0.81) | RAB9ANPC1SMN1; SMN2CYP1A2LMNA | |
| SCHEMBL11781626 | 0.76 | RAB9A (0.56) | RAB9ANPC1SMN1; SMN2CYP1A2LMNA | |
| SCHEMBL30753825 | 0.76 | MAPT (0.65) | RAB9ANPC1SMN1; SMN2CYP1A2POLB | |
| SCHEMBL28302632 | 0.76 | MAPT (0.65) | RAB9ANPC1SMN1; SMN2CYP1A2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | claimed |
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |