Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | HRH2 | P25021 | 1/20 | 0.55 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24365232 | 0.85 | KDM4E (0.56) | OPRK1OPRM1KDM4EALDH1A1GAA | |
| SCHEMBL11488897 | 0.85 | KDM4E (0.56) | OPRK1OPRM1KDM4EALDH1A1GAA | |
| SCHEMBL23747732 | 0.82 | OPRK1 (0.52) | SIGMAR1OPRK1OPRM1KDM4EALDH1A1 | |
| SCHEMBL8543954 | 0.82 | KDM4E (0.64) | SIGMAR1OPRK1OPRM1KDM4EALDH1A1 | |
| SCHEMBL7189631 | 0.81 | OPRK1 (0.55) | OPRK1OPRM1KDM4EALDH1A1KMT2A | |
| SCHEMBL2172790 | 0.81 | CHRNB2 (0.53) | OPRK1OPRM1KDM4EALDH1A1GAA | |
| SCHEMBL22201130 | 0.81 | CHRNB2 (0.53) | OPRK1OPRM1KDM4EALDH1A1GAA | |
| SCHEMBL11707128 | 0.80 | SIGMAR1 (0.51) | SIGMAR1OPRK1OPRM1HRH2 | |
| SCHEMBL23747503 | 0.80 | NPC1 (0.60) | OPRK1OPRM1KDM4EALDH1A1KMT2A | |
| SCHEMBL23747504 | 0.80 | NPC1 (0.60) | OPRK1OPRM1KDM4EALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993004040-A1 | AZACYCLIC COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MERCK SHARP & DOHME LIMITED (GB) | 1993-03-04 | — | — | WO | claimed |