Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 4/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | IL33 | O95760 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26102269 | 0.92 | OPRK1 (0.55) | OPRK1OPRM1ACHEBACE1SIGMAR1 | |
| SCHEMBL28205556 | 0.86 | OPRK1 (0.61) | OPRK1OPRM1SIGMAR1HRH2KDM4E | |
| SCHEMBL9539833 | 0.82 | SIGMAR1 (0.58) | OPRK1OPRM1SIGMAR1KMT2AHRH2 | |
| SCHEMBL23747504 | 0.81 | NPC1 (0.60) | OPRK1OPRM1MEN1KMT2AKDM4E | |
| SCHEMBL23747503 | 0.81 | NPC1 (0.60) | OPRK1OPRM1MEN1KMT2AKDM4E | |
| SCHEMBL28312282 | 0.81 | OPRK1 (0.61) | OPRK1OPRM1SIGMAR1MEN1KMT2A | |
| SCHEMBL26103018 | 0.81 | OPRK1 (0.48) | OPRK1OPRM1ACHEMEN1KMT2A | |
| SCHEMBL26100527 | 0.79 | ACHE (0.47) | OPRK1OPRM1ACHEBACE1SIGMAR1 | |
| SCHEMBL23747562 | 0.75 | NPC1 (0.63) | OPRK1OPRM1MEN1KMT2AKDM4E | |
| SCHEMBL23747507 | 0.75 | GLA (0.48) | OPRK1OPRM1SIGMAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021159015-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. (US) | 2021-08-12 | — | — | WO | disclosed |