Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 3/20 | 0.40 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | VKORC1 | Q9BQB6 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5510275 | 0.73 | KDM4E (0.56) | ALOX5KDM4ETDP1KMT2AALDH1A1 | |
| SCHEMBL9541424 | 0.70 | KDM4E (0.42) | KDM4ETDP1PARP1TNKSTNKS2 | |
| SCHEMBL31716910 | 0.69 | KMT2A (0.80) | MAOBKDM4EPARP1TNKSCYP1A1 | |
| SCHEMBL7696486 | 0.69 | ALDH1A1 (0.54) | KDM4ETDP1KMT2AALDH1A1MEN1 | |
| SCHEMBL9541047 | 0.68 | LOXL2 (0.57) | MAOBKDM4EPARP1TNKSCYP1A1 | |
| SCHEMBL31716561 | 0.68 | LOXL2 (0.57) | MAOBKDM4EPARP1TNKSCYP1A1 | |
| SCHEMBL9540970 | 0.68 | GPR17 (0.52) | PDE3BPDE3A | |
| SCHEMBL9542605 | 0.68 | ALOX5 (0.42) | ALOX5MAOBKDM4EPARP1TNKS | |
| SCHEMBL7823681 | 0.67 | KDM4E (0.51) | KDM4ETDP1PARP1TNKSTNKS2 | |
| SCHEMBL6605700 | 0.66 | MEN1 (0.47) | MAOBKDM4ETDP1PARP1VKORC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993014086-A1 | SUBSTITUTED 1-ISOQUINOLONE DERIVATIVES AS ANGIOTENSIN II ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1993-07-22 | — | — | WO | disclosed |