Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9540355 | 0.90 | KDM4E (0.32) | KDM4EALDH1A1POLBHPGDTP53 | |
| SCHEMBL9539357 | 0.90 | KDM4E (0.34) | KDM4EALDH1A1POLBHPGDCDK1 | |
| SCHEMBL9542967 | 0.86 | CSNK2A2 (0.34) | KDM4ETP53MEN1CSNK2A2RAB9A | |
| SCHEMBL9540192 | 0.86 | CDK1 (0.38) | KDM4EHPGDTP53CDK1CCNB1 | |
| SCHEMBL9539346 | 0.77 | MEN1 (0.32) | HPGDMEN1CSNK2A2RAB9ACSNK2B | |
| SCHEMBL9541784 | 0.77 | MEN1 (0.32) | KDM4ETP53MEN1CSNK2A2RAB9A | |
| SCHEMBL9540494 | 0.70 | KDM4E (0.38) | KDM4EALDH1A1HPGDTP53RAB9A | |
| SCHEMBL9540477 | 0.70 | KDM4E (0.38) | KDM4EALDH1A1HPGDTP53MEN1 | |
| SCHEMBL9543012 | 0.67 | LMNA (0.43) | KDM4EALDH1A1HPGDCDK1CCNB1 | |
| SCHEMBL32675792 | 0.65 | CDK2 (0.51) | KDM4EALDH1A1CDK1CCNB1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993003033-A1 | CARBONATE-SUBSTITUTED IMIDAZO[4,5-d] PYRIDAZINE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G. D. SEARLE & CO. (US) | 1993-02-18 | — | — | WO | claimed |
| WO-1993003033-A1 | CARBONATE-SUBSTITUTED IMIDAZO[4,5-d] PYRIDAZINE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G. D. SEARLE & CO. (US) | 1993-02-18 | — | — | WO | disclosed |