Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11024459 | 0.73 | CCKAR (0.39) | HRH4HRH3SIGMAR1SMN1; SMN2MEN1 | |
| SCHEMBL11149059 | 0.73 | NPSR1 (0.40) | SMN1; SMN2KMT2AKDM4E | |
| SCHEMBL11032087 | 0.73 | HRH4 (0.38) | HRH4HRH3SIGMAR1SMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL8805169 | 0.69 | GAA (0.36) | GAA | |
| SCHEMBL28831505 | 0.68 | GAA (0.39) | GAA | |
| SCHEMBL11145199 | 0.68 | GAA (0.30) | GAA | |
| SCHEMBL9540304 | 0.67 | S1PR2 (0.37) | SMN1; SMN2LMNAKDM4EALDH1A1NLRP3 | |
| SCHEMBL29133228 | 0.66 | KDM4E (0.38) | SMN1; SMN2MEN1KMT2ACYP1A2CYP2D6 | |
| SCHEMBL28859790 | 0.64 | SIGMAR1 (0.55) | HRH4HRH3SIGMAR1SMN1; SMN2KMT2A | |
| SCHEMBL28905184 | 0.64 | GAA (0.32) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993002707-A1 | NEW ANTI-DIARRHEIC AGENTS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1993-02-18 | — | — | WO | claimed |
| WO-1993002707-A1 | NEW ANTI-DIARRHEIC AGENTS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1993-02-18 | — | — | WO | disclosed |
| EP-0170024-A3 | USE OF 2-ACYLAMINOMETHYL-1,4-BENZODIAZEPINE DERIVATIVES FOR THE PRODUCTION OF PHARMACEUTICAL COMPOSITIONS AND PROCESS FOR THE PREPARATION FOR PHARMACEUTICAL COMPOSITIONS | MERCK & CO. INC. (US) | 1990-01-31 | — | — | EP | disclosed |
| EP-0170024-A3 | USE OF 2-ACYLAMINOMETHYL-1,4-BENZODIAZEPINE DERIVATIVES FOR THE PRODUCTION OF PHARMACEUTICAL COMPOSITIONS AND PROCESS FOR THE PREPARATION FOR PHARMACEUTICAL COMPOSITIONS | MERCK & CO. INC. (US) | 1990-01-31 | — | — | EP | disclosed |
| US-4684646-A | CHOLECYSTOKININ-ANTAGONISTS | MERCK & CO., INC. (US) | 1987-08-04 | — | — | US | disclosed |
| US-4684646-A | CHOLECYSTOKININ-ANTAGONISTS | MERCK & CO., INC. (US) | 1987-08-04 | — | — | US | disclosed |
| US-4684646-A | CHOLECYSTOKININ-ANTAGONISTS | MERCK & CO., INC. (US) | 1987-08-04 | — | — | US | disclosed |
| US-4649137-A | ANALGESICS | KALI-CHEMIE PHARMA GMBH (DE) | 1987-03-10 | — | — | US | disclosed |
| US-4649137-A | ANALGESICS | KALI-CHEMIE PHARMA GMBH (DE) | 1987-03-10 | — | — | US | disclosed |
| EP-0170024-A2 | Use of 2-acylaminomethyl-1,4-benzodiazepine derivatives for the production of pharmaceutical compositions and process for the preparation for pharmaceutical compositions | MERCK & CO. INC. (US) | 1986-02-05 | — | — | EP | disclosed |
| EP-0068240-A1 | 2-Acylaminomethyl-1,4-benzodiazepine derivatives, their preparation and intermediates, and pharmaceutical preparations containing them | Kali-Chemie Pharma GmbH (DE) | 1983-01-05 | — | — | EP | disclosed |
| EP-0068240-A1 | 2-Acylaminomethyl-1,4-benzodiazepine derivatives, their preparation and intermediates, and pharmaceutical preparations containing them | Kali-Chemie Pharma GmbH (DE) | 1983-01-05 | — | — | EP | disclosed |
| EP-0066303-A1 | 2-Azidomethyl-1,4-benzodiazepines, their salts, process for preparing them and pharmaceutical compositions containing them | Kali-Chemie Pharma GmbH (DE) | 1982-12-08 | — | — | EP | disclosed |
| EP-0066303-A1 | 2-Azidomethyl-1,4-benzodiazepines, their salts, process for preparing them and pharmaceutical compositions containing them | Kali-Chemie Pharma GmbH (DE) | 1982-12-08 | — | — | EP | disclosed |
| EP-0054839-A2 | 2-Acylaminomethyl-1,4-benzodiazepines and their salts, methods of preparing them and pharmaceutical compositions containing them | Kali-Chemie Pharma GmbH (DE) | 1982-06-30 | — | — | EP | disclosed |
| EP-0054839-A2 | 2-Acylaminomethyl-1,4-benzodiazepines and their salts, methods of preparing them and pharmaceutical compositions containing them | Kali-Chemie Pharma GmbH (DE) | 1982-06-30 | — | — | EP | disclosed |
| US-4325957-A | ANTICONVULSANTS, ANALGESICS, ANTIARRYTHMIA, AGENTS, DIURETICS | KALI-CHEMIE PHARMA GMBH. (DE) | 1982-04-20 | — | — | US | disclosed |
| US-4325957-A | ANTICONVULSANTS, ANALGESICS, ANTIARRYTHMIA, AGENTS, DIURETICS | KALI-CHEMIE PHARMA GMBH. (DE) | 1982-04-20 | — | — | US | disclosed |
| EP-0031080-A1 | 2-Acylaminomethyl-1,4-benzodiazepines and their salts, as well as a process for their preparation and pharmaceutical compositions containing these compounds | Kali-Chemie Pharma GmbH (DE) | 1981-07-01 | — | — | EP | disclosed |
| EP-0031080-A1 | 2-Acylaminomethyl-1,4-benzodiazepines and their salts, as well as a process for their preparation and pharmaceutical compositions containing these compounds | Kali-Chemie Pharma GmbH (DE) | 1981-07-01 | — | — | EP | disclosed |