Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKAR | P32238 | 2/20 | 0.39 |
| ▸ | CCKBR | P32239 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11298881 | 0.77 | CDK2 (0.40) | CCKARCCKBRCHRM1HRH4HRH3 | |
| SCHEMBL9540291 | 0.73 | HRH4 (0.38) | HRH4HRH3SIGMAR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL27552511 | 0.66 | GABRA1 (0.48) | CCKARCCKBRCHRM1GABRA1GABRG2 | |
| Biphenyl SCHEMBL22832517 | 0.65 | SIGMAR1 (0.66) | HRH4HRH3SIGMAR1SOAT1ALDH1A1 | |
| Biphenyl SCHEMBL5716029 | 0.65 | SIGMAR1 (0.66) | HRH4HRH3SIGMAR1SOAT1ALDH1A1 | |
| SCHEMBL11032087 | 0.65 | HRH4 (0.38) | HRH4HRH3SIGMAR1SOAT1SMN1; SMN2 | |
| Biphenyl SCHEMBL27827416 | 0.64 | SIGMAR1 (0.63) | HRH4HRH3SIGMAR1SOAT1ALDH1A1 | |
| SCHEMBL538475 | 0.64 | MAOA (0.76) | HRH4HRH3SIGMAR1SMN1; SMN2MAPT | |
| SCHEMBL1692071 | 0.62 | MAOA (0.80) | HRH4HRH3SIGMAR1SMN1; SMN2MEN1 | |
| SCHEMBL2882451 | 0.62 | MAOA (0.80) | HRH4HRH3SIGMAR1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0054839-B1 | 2-ACYLAMINOMETHYL-1,4-BENZODIAZEPINES AND THEIR SALTS, METHODS OF PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Kali-Chemie Pharma GmbH (DE) | 1985-06-19 | — | — | EP | disclosed |
| EP-0054839-A2 | 2-Acylaminomethyl-1,4-benzodiazepines and their salts, methods of preparing them and pharmaceutical compositions containing them | Kali-Chemie Pharma GmbH (DE) | 1982-06-30 | — | — | EP | disclosed |