Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | APP | P05067 | 6/20 | 0.47 |
| ▸ | SNCA | P37840 | 6/20 | 0.47 |
| ▸ | CCKBR | P32239 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
| ▸ | EP300 | Q09472 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9540886 | 1.00 | MAPT (0.47) | MAPTAPPSNCACCKBRKMT2A | |
| SCHEMBL9774421 | 0.91 | CCKBR (0.43) | MAPTAPPSNCACCKBRKMT2A | |
| SCHEMBL9543560 | 0.91 | CCKBR (0.43) | MAPTAPPSNCACCKBRKMT2A | |
| SCHEMBL9774427 | 0.90 | TRPA1 (0.42) | MAPTAPPSNCAKMT2AMEN1 | |
| SCHEMBL9541539 | 0.90 | TRPA1 (0.42) | MAPTAPPSNCAKMT2AMEN1 | |
| SCHEMBL9540933 | 0.88 | EP300 (0.45) | MAPTAPPSNCAKMT2AMEN1 | |
| SCHEMBL9774452 | 0.88 | EP300 (0.45) | MAPTAPPSNCAKMT2AMEN1 | |
| SCHEMBL9774480 | 0.87 | EP300 (0.48) | KMT2AMEN1PTPN1EP300 | |
| SCHEMBL9540923 | 0.87 | EP300 (0.48) | KMT2AMEN1PTPN1EP300 | |
| SCHEMBL9541860 | 0.86 | APP (0.45) | MAPTAPPSNCACCKBRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993012786-A1 | INDOLINONE DERIVATIVES | HOWARD HARRY R JR (US) | 1993-07-08 | — | — | WO | disclosed |
| US-5064852-A | Antidiabetic agents; aldose reductase inhibitors | PFIZER INC. (US) | 1991-11-12 | — | — | US | disclosed |
| US-4960785-A | Indolinone derivatives | PFIZER INC. (US) | 1990-10-02 | — | — | US | disclosed |
| EP-0252713-B1 | INDOLINONE DERIVATIVES | PFIZER INC. (US) | 1990-09-12 | — | — | EP | disclosed |
| EP-0252713-A1 | Indolinone derivatives | PFIZER INC. (US) | 1988-01-13 | — | — | EP | disclosed |