Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | ALDH2 | P05091 | 3/20 | 0.42 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 2/20 | 0.39 |
| ▸ | APP | P05067 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SNCA | P37840 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9774421 | 1.00 | CCKBR (0.43) | CCKBRMEN1KMT2AALDH1A1ALDH2 | |
| SCHEMBL9540868 | 0.91 | MAPT (0.47) | CCKBRMEN1KMT2AALDH1A1PTPN1 | |
| SCHEMBL9540886 | 0.91 | MAPT (0.47) | CCKBRMEN1KMT2AALDH1A1PTPN1 | |
| SCHEMBL9540923 | 0.86 | EP300 (0.48) | MEN1KMT2APTPN1EP300PPARG | |
| SCHEMBL9774480 | 0.86 | EP300 (0.48) | MEN1KMT2APTPN1EP300PPARG | |
| SCHEMBL9774427 | 0.85 | TRPA1 (0.42) | MEN1KMT2AALDH1A1PTPN1TRPA1 | |
| SCHEMBL9541539 | 0.85 | TRPA1 (0.42) | MEN1KMT2AALDH1A1PTPN1TRPA1 | |
| SCHEMBL9540933 | 0.84 | EP300 (0.45) | MEN1KMT2AALDH1A1PTPN1ABL1 | |
| SCHEMBL9774452 | 0.84 | EP300 (0.45) | MEN1KMT2AALDH1A1PTPN1ABL1 | |
| SCHEMBL17830710 | 0.81 | ALDH1A1 (0.64) | CCKBRKMT2AALDH1A1ALDH2ALDH3A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993012786-A1 | INDOLINONE DERIVATIVES | HOWARD HARRY R JR (US) | 1993-07-08 | — | — | WO | disclosed |
| US-5064852-A | Antidiabetic agents; aldose reductase inhibitors | PFIZER INC. (US) | 1991-11-12 | — | — | US | disclosed |
| US-4960785-A | Indolinone derivatives | PFIZER INC. (US) | 1990-10-02 | — | — | US | disclosed |
| EP-0252713-B1 | INDOLINONE DERIVATIVES | PFIZER INC. (US) | 1990-09-12 | — | — | EP | disclosed |
| EP-0252713-A1 | Indolinone derivatives | PFIZER INC. (US) | 1988-01-13 | — | — | EP | disclosed |