Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 11/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | IP6K1 | Q92551 | 2/20 | 0.43 |
| ▸ | PIM1 | P11309 | 3/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.42 |
| ▸ | RHEB | Q15382 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9541195 | 0.76 | PARP1 (0.62) | PARP1ALDH1A1IP6K1PIM1CHEK1 | |
| SCHEMBL29784205 | 0.73 | PARP1 (1.00) | PARP1ALDH1A1IP6K1PIM1CHEK1 | |
| SCHEMBL2191006 | 0.73 | PARP1 (1.00) | PARP1ALDH1A1IP6K1PIM1CHEK1 | |
| SCHEMBL29898482 | 0.73 | ALDH1A1 (1.00) | PARP1ALDH1A1IP6K1PIM1CHEK1 | |
| SCHEMBL643424 | 0.73 | ALDH1A1 (1.00) | PARP1ALDH1A1IP6K1PIM1CHEK1 | |
| SCHEMBL5204396 | 0.72 | PTGS1 (0.43) | PARP1ALDH1A1PIM1RHEBMAP2K2 | |
| SCHEMBL25759220 | 0.70 | IP6K1 (0.56) | PARP1ALDH1A1IP6K1PIM1CHEK1 | |
| SCHEMBL15890147 | 0.70 | PARP1 (0.56) | PARP1ALDH1A1IP6K1PIM1CHEK1 | |
| SCHEMBL6227029 | 0.69 | PARP1 (0.48) | PARP1ALDH1A1IP6K1PIM1CHEK1 | |
| SCHEMBL9541519 | 0.69 | IP6K1 (0.68) | PARP1IP6K1PIM1CHEK1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993012795-A1 | QUINAZOLIN-4(3H)-ONE DERIVATIVES AS ANTICOCCIDIAL AGENTS | GLAZER EDWARD A (US) | 1993-07-08 | — | — | WO | disclosed |
| US-4920224-A | CHEMICAL INTERMEDIATES | PFIZER INC. (US) | 1990-04-24 | — | — | US | disclosed |
| US-4849518-A | ANTIPROTOZOA IN POULTRY | PFIZER INC. (US) | 1989-07-18 | — | — | US | disclosed |
| US-4762838-A | Quinazolin-4(3H)-one derivatives as anticoccidial agents | PFIZER INC. (US) | 1988-08-09 | — | — | US | disclosed |