SCHEMBL9541652

SCHEMBL9541652

C[Si](C)(C)OC1CCN(c2ccc(C=O)cn2)CC1

nearest known ligand 0.57

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 15/20 0.42
KCNJ1 P48048 1/20 0.40
MAPT P10636 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31047813 0.81 ADRA1A (0.47) HRH3KCNJ1
SCHEMBL14235869 0.81 HRH3 (0.42) HRH3KCNJ1
SCHEMBL9537580 0.79 AKR1C3 (0.46) HRH3MAPT
SCHEMBL14235512 0.79 KCNJ1 (0.44) HRH3KCNJ1MAPT
SCHEMBL24411118 0.76 PDE10A (0.46) HRH3KCNJ1MAPT
SCHEMBL13082629 0.76 KCNJ1 (0.42) KCNJ1MAPT
SCHEMBL1735017 0.76 TRIM24 (0.53) KCNJ1MAPT
SCHEMBL14127751 0.75 DGAT1 (0.61) HRH3
SCHEMBL14127680 0.75 DGAT1 (0.61) HRH3
SCHEMBL14127679 0.75 DGAT1 (0.61) HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1993006118-A1 ANTIBACTERIAL, ANTIMYCOPLASMAL COMPOUNDS RELATED TO MUPIROCIN SMITHKLINE BEECHAM PLC (GB) 1993-04-01 WO disclosed