Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.37 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.37 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9774461 | 0.79 | TDP1 (0.42) | TDP1ALDH1A1LMNAOPRL1L3MBTL1 | |
| SCHEMBL15156486 | 0.76 | TP53 (0.52) | ALDH1A1LMNAOPRL1MAPTL3MBTL1 | |
| SCHEMBL17830714 | 0.74 | PTGDR2 (0.51) | — | |
| SCHEMBL9544593 | 0.73 | OPRL1 (0.50) | ALDH1A1LMNAOPRL1L3MBTL1 | |
| SCHEMBL9543551 | 0.73 | OPRL1 (0.48) | ALDH1A1LMNAOPRL1L3MBTL1 | |
| Water SCHEMBL9542351 | 0.72 | HSD17B10 (0.45) | TDP1ALDH1A1LMNAGAAMAPT | |
| SCHEMBL7638188 | 0.71 | ALDH1A1 (0.67) | ALDH1A1MAPTL3MBTL1NPSR1TSHR | |
| SCHEMBL9774451 | 0.71 | PRKAG1 (0.43) | TDP1ALDH1A1MAPTL3MBTL1NPSR1 | |
| SCHEMBL9541868 | 0.71 | PRKAG1 (0.43) | TDP1ALDH1A1MAPTL3MBTL1NPSR1 | |
| SCHEMBL4259311 | 0.71 | ALDH1A1 (0.41) | TDP1ALDH1A1LMNAGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993012786-A1 | INDOLINONE DERIVATIVES | HOWARD HARRY R JR (US) | 1993-07-08 | — | — | WO | disclosed |
| US-5064852-A | Antidiabetic agents; aldose reductase inhibitors | PFIZER INC. (US) | 1991-11-12 | — | — | US | disclosed |
| US-4960785-A | Indolinone derivatives | PFIZER INC. (US) | 1990-10-02 | — | — | US | disclosed |
| EP-0252713-B1 | INDOLINONE DERIVATIVES | PFIZER INC. (US) | 1990-09-12 | — | — | EP | disclosed |
| EP-0252713-A1 | Indolinone derivatives | PFIZER INC. (US) | 1988-01-13 | — | — | EP | disclosed |