Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAG1 | P54619 | 7/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 7/20 | 0.43 |
| ▸ | PRKAB1 | Q9Y478 | 7/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CCKBR | P32239 | 1/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9541868 | 1.00 | PRKAG1 (0.43) | PRKAG1PRKAA2PRKAB1TDP1ALDH1A1 | |
| SCHEMBL9540868 | 0.77 | MAPT (0.47) | TDP1ALDH1A1MAPTCCKBRAPAF1 | |
| SCHEMBL9540886 | 0.77 | MAPT (0.47) | TDP1ALDH1A1MAPTCCKBRAPAF1 | |
| SCHEMBL1444562 | 0.74 | POLB (0.54) | PRKAG1PRKAA2PRKAB1ALDH1A1AGTR1 | |
| SCHEMBL1444561 | 0.74 | POLB (0.54) | PRKAG1PRKAA2PRKAB1ALDH1A1AGTR1 | |
| SCHEMBL17830710 | 0.71 | ALDH1A1 (0.64) | ALDH1A1MAPTCCKBRCTRB1KMT2A | |
| SCHEMBL9543560 | 0.71 | CCKBR (0.43) | TDP1ALDH1A1MAPTCCKBRTSHR | |
| SCHEMBL9774421 | 0.71 | CCKBR (0.43) | TDP1ALDH1A1MAPTCCKBRTSHR | |
| SCHEMBL1444194 | 0.71 | CA12 (0.53) | PRKAG1PRKAA2PRKAB1ALDH1A1MAPT | |
| SCHEMBL1444193 | 0.71 | CA12 (0.53) | PRKAG1PRKAA2PRKAB1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5064852-A | Antidiabetic agents; aldose reductase inhibitors | PFIZER INC. (US) | 1991-11-12 | — | — | US | disclosed |
| US-4960785-A | Indolinone derivatives | PFIZER INC. (US) | 1990-10-02 | — | — | US | disclosed |
| EP-0252713-B1 | INDOLINONE DERIVATIVES | PFIZER INC. (US) | 1990-09-12 | — | — | EP | disclosed |