Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 9/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MLNR | O43193 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535563 | 0.81 | TP53 (0.51) | ALDH1A1GAALMNAHRH1CYP2D6 | |
| SCHEMBL9536075 | 0.76 | HRH1 (0.62) | GAALMNAHRH1CYP2D6TP53 | |
| Hydrochloric Acid SCHEMBL9537053 | 0.74 | KCNH2 (0.62) | HRH1CYP2D6TP53KCNH2CHRM1 | |
| SCHEMBL9537447 | 0.73 | SSTR5 (0.49) | HRH1TP53MAPTKCNH2TACR2 | |
| SCHEMBL10548426 | 0.72 | TP53 (0.49) | ALDH1A1GAALMNAHRH1CYP2D6 | |
| SCHEMBL9536278 | 0.71 | SSTR5 (0.49) | GAALMNAHRH1CYP2D6TP53 | |
| SCHEMBL10799113 | 0.71 | LMNA (0.51) | ALDH1A1GAALMNAHRH1CYP2D6 | |
| SCHEMBL10546904 | 0.70 | HRH1 (0.46) | GAALMNAHRH1CYP2D6POLB | |
| SCHEMBL15569315 | 0.70 | HRH1 (0.62) | ALDH1A1GAALMNAHRH1CYP2D6 | |
| SCHEMBL9537124 | 0.69 | LMNA (0.48) | LMNAHRH1CYP2D6MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |