SCHEMBL9541983

SCHEMBL9541983

C[C@]1(O)CC[C@H]2[C@@H]3CCC4=C/C(=N/OS(C)(=O)=O)CC[C@@H]4[C@H]3CC[C@@]21C

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDK1 Q15118 4/20 0.53
PDK2 Q15119 4/20 0.53
PDK3 Q15120 4/20 0.53
PDK4 Q16654 4/20 0.53
CYP3A4 P08684 3/20 0.48
ABCB11 O95342 3/20 0.48
LMNA P02545 3/20 0.48
PGR P06401 3/20 0.48
CYP2C19 P33261 2/20 0.48
NR3C1 P04150 2/20 0.48
TSHR P16473 1/20 0.48
HIF1A Q16665 1/20 0.48
ALDH1A1 P00352 1/20 0.48
ESR1 P03372 1/20 0.48
SHBG P04278 1/20 0.48
ADRA2A P08913 1/20 0.48
SLC6A4 P31645 1/20 0.48
MAPT P10636 3/20 0.43
AR P10275 2/20 0.43
CHRM2 P08172 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9541216 0.82 PDK1 (0.74) PDK1PDK2PDK3PDK4CYP3A4
SCHEMBL9541966 0.82 PDK1 (0.43) PDK1PDK2PDK3PDK4CYP3A4
SCHEMBL9543737 0.78 SHBG (0.62) CYP3A4LMNAPGRCYP2C19NR3C1
Normethandrone SCHEMBL23801610 0.78 PGR (0.73) CYP3A4ABCB11LMNAPGRCYP2C19
Normethandrone SCHEMBL148631 0.78 PGR (0.73) CYP3A4ABCB11LMNAPGRCYP2C19
Normethandrone SCHEMBL148632 0.78 PGR (0.73) CYP3A4ABCB11LMNAPGRCYP2C19
SCHEMBL9540903 0.78 PGR (0.36) PDK1PDK2PDK3PDK4CYP3A4
SCHEMBL9542637 0.74 SHBG (0.43) ABCB11LMNAPGRCYP2C19NR3C1
SCHEMBL9542667 0.74 SHBG (0.43) CYP3A4LMNAPGRCYP2C19NR3C1
SCHEMBL9542907 0.70 SHBG (0.64) PGRNR3C1ALDH1A1SHBGAR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1993013122-A1 3-METHYLSULPHONYLHYDRAZONO AND 3-OXYIMINO STEROIDS, A METHOD OF PREPARING THEM, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND THEIR USE IN THE PREPARATION OF DRUGS SCHERING AKTIENGESELLSCHAFT (DE) 1993-07-08 WO claimed
WO-1993013122-A1 3-METHYLSULPHONYLHYDRAZONO AND 3-OXYIMINO STEROIDS, A METHOD OF PREPARING THEM, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND THEIR USE IN THE PREPARATION OF DRUGS SCHERING AKTIENGESELLSCHAFT (DE) 1993-07-08 WO disclosed