Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 4/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.50 |
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | HBB | P68871 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19135849 | 0.77 | DHFR (0.43) | DHFRSLC2A1KMT2A | |
| SCHEMBL9541803 | 0.74 | CYP1A2 (0.44) | DHFRSLC2A1ALDH1A1MAPTHTT | |
| SCHEMBL26597052 | 0.71 | BRPF1 (0.62) | PRKCIBRPF1KDM4ERAD52ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9568495 | 0.71 | DHFR (0.50) | DHFRSLC2A1PRKCIBRPF1KDM4E | |
| SCHEMBL8045718 | 0.71 | CCR2 (0.47) | PRKCIBRPF1KDM4EALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL9568498 | 0.69 | TLR8 (0.45) | PRKCIBRPF1KDM4ERAD52ALDH1A1 | |
| SCHEMBL28372163 | 0.69 | DHFR (0.52) | DHFRSLC2A1KDM4EALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL27399297 | 0.68 | TSHR (0.40) | DHFRSLC2A1PRKCIBRPF1KDM4E | |
| SCHEMBL9541715 | 0.67 | DHFR (1.00) | DHFRSLC2A1 | |
| SCHEMBL12967738 | 0.67 | BRPF1 (0.45) | PRKCIBRPF1KDM4ERAD52ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1073175-A | Heterogeneous ring compound | WELLCOME FOUND (GB) | 1993-06-16 | — | — | CN | disclosed |
| WO-1993010119-A1 | HETEROCYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-05-27 | — | — | WO | disclosed |
| EP-0542497-A1 | Heterocyclic compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-05-19 | — | — | EP | disclosed |