SCHEMBL95434

SCHEMBL95434

O=[C]c1ccc(Cl)cc1Cl

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TP53 P04637 3/20 0.48
TDP1 Q9NUW8 3/20 0.43
TSHR P16473 7/20 0.42
CYP3A4 P08684 4/20 0.42
HSD17B10 Q99714 2/20 0.42
CASP1 P29466 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
MAPK1 P28482 4/20 0.40
VCAM1 P19320 1/20 0.38
IDO1 P14902 1/20 0.38
ALDH1A1 P00352 3/20 0.38
HIF1A Q16665 1/20 0.38
CYP1A2 P05177 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
AHR P35869 1/20 0.37
KDM4E B2RXH2 1/20 0.36
MAPT P10636 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28296077 0.91 FSCN1 (0.43) TP53TDP1TSHRCYP3A4HSD17B10
SCHEMBL11507070 0.82 VCAM1 (0.39) TP53TDP1TSHRCYP3A4HSD17B10
SCHEMBL95478 0.80 TP53 (0.48) TP53TDP1TSHRCYP3A4HSD17B10
SCHEMBL102884 0.78 TRPV4 (0.34) TDP1MAPK1
SCHEMBL96822 0.76 CYP11B2 (0.36) ALDH1A1
SCHEMBL2701308 0.76 VCAM1 (0.36) TP53TDP1TSHRCYP3A4SMN1; SMN2
SCHEMBL7241609 0.76 CYP3A4 (0.52) TDP1TSHRCYP3A4HSD17B10CASP1
SCHEMBL5127052 0.76 FFAR1 (0.43) TP53TSHRCYP3A4SMN1; SMN2MAPK1
SCHEMBL21201454 0.76 IDO1 (0.37) TDP1MAPK1IDO1
SCHEMBL6146245 0.76 TSHR (0.52) TP53TDP1TSHRCYP3A4HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1707 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4399212-A1 SUBSTITUTED 2,3-DIHYDRO[1,3]THIAZOLO[4,5-B]PYRIDINES, SALTS THEREOF AND THEIR USE AS HERBICIDALLY ACTIVE SUBSTANCES Bayer Aktiengesellschaft (DE) 2024-07-17 EP claimed
CN-118271535-A Resin composition, prepreg and copper-clad laminate manufactured by using resin composition 广东生益科技股份有限公司 2024-07-02 CN claimed
CN-118159542-A Substituted 2, 3-dihydro [1,3] thiazolo [4,5-b ] pyridines, salts thereof and their use as herbicidal agents 拜耳公司 2024-06-07 CN claimed
CN-117625104-A Epoxy resin adhesive composition 西安道生化工科技有限公司 2024-03-01 CN claimed
CN-117024968-A Thermal insulation foaming ceramic silica gel and preparation method thereof 苏州铂韬新材料科技有限公司 2023-11-10 CN claimed
EP-3663351-B1 THERMOSETTING RESIN COMPOSITION, AND PREPREG AND METAL FOIL CLAD LAMINATE PREPARED FROM SAME SHENGYI TECHNOLOGY CO LTD (CN) 2023-08-23 EP claimed
CN-116178968-A Ceramic low-smoke low-toxicity flame-retardant silicone rubber material and preparation method thereof 应急管理部四川消防研究所 2023-05-30 CN claimed
EP-3666754-B1 FULLY CONTINUOUS FLOW PRODUCTION PROCESS FOR DIRECTLY PREPARING ORGANIC PEROXIDE FROM ALCOHOL OR ALKANE SHANGHAI HYBRID CHEM TECH (CN) 2023-03-29 EP claimed
WO-2023036707-A1 SUBSTITUTED 2,3-DIHYDRO[1,3]THIAZOLO[4,5-B]PYRIDINES, SALTS THEREOF AND THEIR USE AS HERBICIDALLY ACTIVE SUBSTANCES BAYER AKTIENGESELLSCHAFT (DE) 2023-03-16 WO claimed
CN-115557895-A Pyrazole derivative and preparation method and application thereof 贵州大学 2023-01-03 CN claimed
EP-0080338-B1 POLYMERIZATION OF POLYOL (ALLYL CARBONATE) USING POLYMERIZATION INITIATORS OF SHORT AND LONG HALF LIVES PPG INDUSTRIES, INC. (US) 1986-05-07 EP claimed
EP-0078663-B1 FUNGICIDAL N-PHENYLCARBAMATES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1985-04-17 EP claimed
EP-0078663-A2 Fungicidal N-phenylcarbamates SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1983-05-11 EP claimed
US-4369275-A PHOTOSTABILITY FOR POLYMERS CIBA-GEIGY AG (CH) 1983-01-18 US claimed
EP-0019440-B1 BENZIMIDAZOLONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM PFIZER INC. (US) 1982-09-29 EP claimed
EP-0047200-A2 Method of painting a substrate, and its use in road marking COMMISSARIAT A L'ENERGIE ATOMIQUE Etablissement de Caractère Scientifique Technique et Industriel (FR) 1982-03-10 EP claimed
US-4293468-A Malonate derivatives as stabilizers for organic materials CIBA-GEIGY AG (CH) 1981-10-06 US claimed
US-4010193-A (ALKYLAMINO)ALKYL SUBSTITUTED BENZOATES, LOCAL ANESTHETIC, ANTIFIBRILLATORY, ANTIARRHYTHMIAL CHINOIN GYOGYSZER-ES VEGYESZETI TERMEKEK GYARA RT (HU) 1977-03-01 US claimed
US-3951964-A Method for preparing azines PRODUITS CHIMIQUES UGINE KUHLMANN (FR) 1976-04-20 US claimed
US-3947450-A Benzoxanthene and benzothioxanthene dicarboxylic acid imide dyestuffs and process for their manufacture HOECHST AKTIENGESELLSCHAFT (DT) 1976-03-30 US claimed