SCHEMBL9543799

SCHEMBL9543799

C=C1C[C@@H]2[C@H](CC[C@@]3(C)[C@H]2CC[C@]3(C)O)[C@@]2(C)CC/C(=N\NS(C)(=O)=O)C=C12

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SHBG P04278 4/20 0.43
ALDH1A1 P00352 4/20 0.43
NR3C1 P04150 3/20 0.43
PGR P06401 3/20 0.43
HTR2B P41595 2/20 0.43
ADRA1A P35348 1/20 0.43
GUSB P08236 1/20 0.40
CYP17A1 P05093 1/20 0.40
SLC10A1 Q14973 1/20 0.38
ESR1 P03372 3/20 0.38
AR P10275 3/20 0.38
ESR2 Q92731 3/20 0.38
CYP19A1 P11511 2/20 0.37
ABCB11 O95342 2/20 0.37
KDM4E B2RXH2 1/20 0.37
HTR2A P28223 1/20 0.37
OPRK1 P41145 1/20 0.37
CYP2C19 P33261 1/20 0.36
LMNA P02545 3/20 0.36
MAPT P10636 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9542637 0.84 SHBG (0.43) SHBGALDH1A1NR3C1PGRHTR2B
SCHEMBL9541924 0.83 SHBG (0.47) SHBGALDH1A1NR3C1PGRHTR2B
SCHEMBL9542789 0.83 SHBG (0.62) SHBGALDH1A1NR3C1PGRHTR2B
SCHEMBL9544771 0.80 SHBG (0.43) SHBGALDH1A1NR3C1PGRHTR2B
SCHEMBL9541254 0.80 SHBG (0.39) SHBGALDH1A1NR3C1PGRHTR2B
SCHEMBL9128581 0.79 SHBG (0.65) SHBGALDH1A1NR3C1PGRHTR2B
SCHEMBL9128571 0.79 SHBG (0.65) SHBGALDH1A1NR3C1PGRHTR2B
SCHEMBL9544741 0.76 SHBG (0.44) SHBGALDH1A1NR3C1PGRHTR2B
SCHEMBL9542595 0.72 SHBG (0.47) SHBGALDH1A1NR3C1PGRHTR2B
SCHEMBL9125438 0.71 ALDH1A1 (0.48) SHBGALDH1A1NR3C1PGRHTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1993013122-A1 3-METHYLSULPHONYLHYDRAZONO AND 3-OXYIMINO STEROIDS, A METHOD OF PREPARING THEM, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND THEIR USE IN THE PREPARATION OF DRUGS SCHERING AKTIENGESELLSCHAFT (DE) 1993-07-08 WO claimed
WO-1993013122-A1 3-METHYLSULPHONYLHYDRAZONO AND 3-OXYIMINO STEROIDS, A METHOD OF PREPARING THEM, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND THEIR USE IN THE PREPARATION OF DRUGS SCHERING AKTIENGESELLSCHAFT (DE) 1993-07-08 WO disclosed