Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.44 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | EDNRA | P25101 | 2/20 | 0.40 |
| ▸ | EDNRB | P24530 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11353385 | 0.71 | HSD11B1 (0.46) | HSD11B1MAPK1 | |
| SCHEMBL9527735 | 0.69 | LMNA (0.42) | KMT2AMAPTMAPK1MEN1 | |
| SCHEMBL27359306 | 0.69 | HDAC9 (0.55) | KIF11KMT2ANPC1MAPTMAPK1 | |
| SCHEMBL11079554 | 0.68 | HSD11B1 (0.47) | HSD11B1KMT2ANPC1MAPTMAPK1 | |
| SCHEMBL11799039 | 0.68 | AKR1C1 (0.40) | KIF11HSD11B1MAPT | |
| SCHEMBL378469 | 0.68 | HSD11B1 (0.47) | HSD11B1KMT2ANPC1MAPTMAPK1 | |
| SCHEMBL9543856 | 0.68 | EDNRA (0.46) | KIF11SLC6A12HSD11B1KMT2ANPC1 | |
| SCHEMBL6071126 | 0.66 | GAA (0.40) | KMT2AMAPT | |
| SCHEMBL8347525 | 0.66 | ATM (0.48) | SLC6A12HSD11B1KMT2ANPC1MAPT | |
| SCHEMBL25986510 | 0.65 | DRD1 (0.45) | KIF11OPRM1OPRL1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993008799-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-05-13 | — | — | WO | disclosed |