Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.33 |
| ▸ | GPR3 | P46089 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28445883 | 0.83 | MAOA (0.33) | CYP2D6HTR2AKMT2AMEN1 | |
| SCHEMBL5323003 | 0.73 | ATM (0.39) | HDAC3HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL647672 | 0.69 | — | — | |
| SCHEMBL8415579 | 0.65 | CYP2D6 (0.39) | CYP2D6HDAC3HDAC4HDAC7HDAC8 | |
| SCHEMBL29469332 | 0.65 | GPR3 (0.46) | CYP2D6HDAC3HDAC4HDAC7HDAC8 | |
| SCHEMBL29503342 | 0.65 | GPR3 (0.46) | CYP2D6HDAC3HDAC4HDAC7HDAC8 | |
| SCHEMBL216862 | 0.65 | MAOA (0.52) | CYP2D6HDAC3HDAC4HDAC7HDAC8 | |
| SCHEMBL29884836 | 0.65 | MAOA (0.52) | CYP2D6HDAC3HDAC4HDAC7HDAC8 | |
| SCHEMBL6903531 | 0.65 | GPR3 (0.46) | CYP2D6HDAC3HDAC4HDAC7HDAC8 | |
| SCHEMBL29376368 | 0.65 | MAOA (0.52) | CYP2D6HDAC3HDAC4HDAC7HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993020695-A1 | POLYHYDROXYLATED DIBENZ (C,E) AZEPINES AS PROTEIN KINASE C INHIBITORS | SPHINX PHARMACEUTICALS CORPORATION (US) | 1993-10-28 | — | — | WO | disclosed |