SCHEMBL647672

SCHEMBL647672

C1=NC2C(=Cc3ccccc32)c2ccccc21

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6448210 0.98
Hydrochloric Acid SCHEMBL645056 0.98
SCHEMBL9545204 0.69 CYP2D6 (0.34)
SCHEMBL23513879 0.68 EDNRA (0.32)
SCHEMBL4036247 0.68
SCHEMBL29354632 0.65 KDM1A (0.37)
SCHEMBL29672901 0.64 DRD2 (0.46)
SCHEMBL6168467 0.64 GPR84 (0.33)
SCHEMBL28445883 0.63 MAOA (0.33)
SCHEMBL339681 0.63

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 127 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011130677-A1 INHIBITORS OF CANCER STEM CELLS UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2011-10-20 WO claimed
US-20250074917-A1 Preparation and Uses of 7-Azaindenoisoquinolines PURDUE RESEARCH FOUNDATION 2025-03-06 US disclosed
CN-119497715-A Preparation and application of 7-aza-indeno isoquinoline 珀杜研究基金会 2025-02-21 CN disclosed
EP-4507736-A1 COMBINATION THERAPY FOR TREATING TROP-2 EXPRESSING CANCERS GILEAD SCIENCES, INC. (US) 2025-02-19 EP disclosed
US-20240287089-A1 Preparation and Uses of 7-Azaindenoisoquinolines PURDUE RESEARCH FOUNDATION (US) 2024-08-29 US disclosed
WO-2024097812-A1 THERAPY FOR TREATING BLADDER CANCER GILEAD SCIENCES, INC. (US) 2024-05-10 WO disclosed
WO-2023215238-A1 PREPARATION AND USES OF 7-AZAINDENOISOQUINOLINES PURDUE RESEARCH FOUNDATION (US) 2023-11-09 WO disclosed
WO-2023201267-A1 COMBINATION THERAPY FOR TREATING TROP-2 EXPRESSING CANCERS GILEAD SCIENCES, INC. (US) 2023-10-19 WO disclosed
EP-3480187-B1 METHOD FOR PREPARING INDENOISOQUINOLINE DERIVATIVES UNIV NAT TAIWAN NORMAL (TW) 2023-10-04 EP disclosed
US-20230219895-A1 OXYNITIDINE DERIVATIVES USEFUL AS INHIBITORS OF TOPOISOMERASE IB (TOP1) AND TYROSYL-DNA PHOSPHODIESTERASE 1 (TDP1) SHENZHEN XUHUA BIOTECH CO. LTD. (CN) 2023-07-13 US disclosed
US-20030171392-A1 Substituted indeno[1,2-c]isoquinoline derivatives and methods of use thereof INOTEK PHARMACEUTICALS CORPORATION 2003-09-11 US disclosed
EP-1335974-A2 CRYSTAL COMPOSITIONS COMPRISING TOPOISOMERASE I Emerald Biostructures Inc. (US) 2003-08-20 EP disclosed
US-20030096833-A1 Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof INOTEK PHARMACEUTICALS CORPORATION 2003-05-22 US disclosed
US-20030096833-A1 Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof INOTEK PHARMACEUTICALS CORPORATION 2003-05-22 US disclosed
US-20030096833-A1 Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof INOTEK PHARMACEUTICALS CORPORATION 2003-05-22 US disclosed
WO-2003020700-A2 SUBSTITUTED INDENO[1,2-c]ISOQUINOLINE DERIVATIVES AND METHODS OF USE THEREOF INOTEK PHARMACEUTICALS CORPORATION (US) 2003-03-13 WO disclosed
WO-2003020700-A2 SUBSTITUTED INDENO[1,2-c]ISOQUINOLINE DERIVATIVES AND METHODS OF USE THEREOF INOTEK PHARMACEUTICALS CORPORATION (US) 2003-03-13 WO disclosed
WO-2002040653-A2 CHRYSTAL COMPOSITIONS COMPRISING TOPOISOMERASE I EMERALD BIOSTRUCTURES, INC. (US) 2002-05-23 WO disclosed
US-5597831-A 6-[X-(2-hydroxyethyl) aminoalkyl]-5,11-dioxo-5,6-dihydro-11-H-indeno[1,2-c]isoquinolines and their use as antineoplastic agents VUFB A.S (CS) 1997-01-28 US disclosed
EP-0643699-B1 6-(2-HYDROXYETHYLAMINOALKYL)-5,11-DIOXO-5,6-DIHYDRO-11H- INDENO[1,2-C]ISOQUINOLINES AND THEIR USE AS ANTINEOPLASTIC AGENTS VUFB AS (CZ) 1996-10-23 EP disclosed