Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.50 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9546969 | 1.00 | LMNA (0.62) | LMNASMN1; SMN2RECQLALDH1A1HPGD | |
| SCHEMBL9547052 | 0.81 | KCNQ3 (0.52) | LMNASMN1; SMN2ALDH1A1KDM4EKMT2A | |
| SCHEMBL9546966 | 0.78 | LMNA (0.48) | LMNASMN1; SMN2ALDH1A1HPGDGAA | |
| SCHEMBL9546970 | 0.78 | LMNA (0.48) | LMNASMN1; SMN2ALDH1A1HPGDGAA | |
| SCHEMBL8886108 | 0.76 | MEN1 (0.64) | LMNARECQLALDH1A1HPGDGAA | |
| SCHEMBL19884283 | 0.76 | RECQL (0.87) | LMNASMN1; SMN2RECQLALDH1A1HPGD | |
| SCHEMBL14314483 | 0.76 | RECQL (0.87) | LMNASMN1; SMN2RECQLALDH1A1HPGD | |
| SCHEMBL15038846 | 0.76 | RECQL (0.87) | LMNASMN1; SMN2RECQLALDH1A1HPGD | |
| SCHEMBL3496402 | 0.75 | ALDH1A1 (0.78) | LMNAALDH1A1GAAKDM4EKMT2A | |
| SCHEMBL15420706 | 0.74 | SLC6A3 (0.48) | LMNARECQLALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0248435-B1 | PROCESS FOR PREPARING 7-OXABICYCLOHEPTANE AMINO-ALCOHOL INTERMEDIATES USEFUL IN MAKING THROMBOXANE A2 RECEPTOR ANTAGONISTS AND NOVEL INTERMEDIATES PRODUCED THEREIN | E.R. Squibb & Sons, Inc. (US) | 1993-03-17 | — | — | EP | disclosed |
| US-4958036-A | Enantiomerically selective synthesis of certain N-substituted-2-(carbamyl 7-oxabicyclo[2.2.1]heptane-3-carboxylic acids | E. R. SQUIBB & SONS, INC. (US) | 1990-09-18 | — | — | US | disclosed |
| US-4851553-A | 7-oxabicycloheptane amido-carboxylic acids | E. R. SQUIBB & SONS, INC. (US) | 1989-07-25 | — | — | US | disclosed |
| US-4816579-A | 7-oxabicycloheptane amino-alcohol intermediates useful in making thromboxane A2 receptor antagonists | E. R. SQUIBB & SONS, INC. (US) | 1989-03-28 | — | — | US | disclosed |
| US-4687865-A | Process for preparing 7-oxabicycloheptane amino-alcohol intermediates useful in making thromboxane A2 receptor antagonists | E. R. SQUIBB & SONS, INC. (US) | 1987-08-18 | — | — | US | disclosed |