Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 known ✓ | P00734 | 2/20 | 0.60 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.60 |
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.60 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.60 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.60 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.60 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.60 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.60 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.60 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.60 |
| ▸ | GRIN1 known ✓ | Q05586 | 1/20 | 0.60 |
| ▸ | GRIN2A known ✓ | Q12879 | 1/20 | 0.60 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.61 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.60 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.60 |
| ▸ | PLAU | P00749 | 1/20 | 0.60 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.60 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.60 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.60 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9547468 | 1.00 | LTB4R (0.61) | LTB4RPRMT1F2ST14PLAU | |
| SCHEMBL9547469 | 0.99 | LTB4R (0.59) | LTB4RPRMT1F2ST14PLAU | |
| SCHEMBL9547445 | 0.92 | PRMT1 (0.71) | LTB4RPRMT1F2ST14PLAU | |
| SCHEMBL9547432 | 0.91 | PRMT1 (0.58) | LTB4RPRMT1F2ST14PLAU | |
| SCHEMBL9547439 | 0.91 | PRMT1 (0.58) | PRMT1F2ST14PLAUPRMT5 | |
| SCHEMBL9547458 | 0.91 | ALDH1A1 (0.55) | LTB4RPRMT1F2ST14PLAU | |
| SCHEMBL9547443 | 0.90 | PRMT1 (0.57) | LTB4RPRMT1F2ST14PLAU | |
| SCHEMBL9547441 | 0.89 | LTB4R (0.63) | LTB4RPRMT1F2ST14PLAU | |
| SCHEMBL9547448 | 0.88 | ALDH1A1 (0.55) | LTB4RPRMT1F2ST14PLAU | |
| SCHEMBL9547440 | 0.88 | ALDH1A1 (0.55) | PRMT1F2ST14PLAUPRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5246965-A | Leukotriene antagonist | CIBA-GEIGY (US) | 1993-09-21 | — | — | US | disclosed |