Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHBG | P04278 | 4/20 | 0.47 |
| ▸ | PGR | P06401 | 4/20 | 0.47 |
| ▸ | AR | P10275 | 4/20 | 0.47 |
| ▸ | ESR1 | P03372 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.42 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11140879 | 0.84 | PGR (0.52) | SHBGPGRARESR1OPRM1 | |
| SCHEMBL3643471 | 0.80 | CYP19A1 (0.62) | SHBGPGRARESR1CYP19A1 | |
| SCHEMBL13372732 | 0.80 | CYP19A1 (0.62) | SHBGPGRARESR1CYP19A1 | |
| SCHEMBL9547819 | 0.80 | ESR1 (0.33) | SHBGPGRARESR1OPRM1 | |
| SCHEMBL9547847 | 0.79 | CYP19A1 (0.64) | SHBGPGRARESR1OPRM1 | |
| SCHEMBL22648669 | 0.75 | SHBG (0.64) | SHBGPGRARESR1OPRM1 | |
| SCHEMBL11146210 | 0.71 | PGR (0.47) | SHBGPGRARESR1OPRM1 | |
| SCHEMBL20851689 | 0.70 | AR (0.58) | SHBGPGRARESR1OPRM1 | |
| SCHEMBL14946867 | 0.70 | AR (0.58) | SHBGPGRARESR1OPRM1 | |
| SCHEMBL15515496 | 0.70 | AR (0.58) | SHBGPGRARESR1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5236913-A | Powerful gestagenic properties and only slight androgenic side effects | AKZO N.V. (NL) | 1993-08-17 | — | — | US | disclosed |
| EP-0210678-B1 | NOVEL LL-METHYLENE-OESTR-15-ENES, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS | AKZO N.V. (NL) | 1989-09-20 | — | — | EP | disclosed |
| EP-0210678-A1 | Novel ll-methylene-oestr-15-enes, processes for their preparation, and pharmaceutical compositions | AKZO N.V. (NL) | 1987-02-04 | — | — | EP | disclosed |