SCHEMBL9547873

SCHEMBL9547873

Cc1ccc(C(O)C#CC(O)c2ccc(C)cc2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 1/20 0.42
ACHE P22303 3/20 0.42
TDP1 Q9NUW8 1/20 0.42
ALDH1A1 P00352 3/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
FFAR1 O14842 1/20 0.38
CACNA2D1 P54289 1/20 0.37
CACNB2 Q08289 1/20 0.37
CACNA1C Q13936 1/20 0.37
ALOX5 P09917 1/20 0.36
TSHR P16473 1/20 0.36
LMNA P02545 2/20 0.35
CES2 O00748 1/20 0.35
CES1 P23141 1/20 0.35
CYP2A6 P11509 1/20 0.35
CA2 P00918 1/20 0.35
LPL P06858 1/20 0.35
LIPG Q9Y5X9 1/20 0.35
ORAI1 Q96D31 1/20 0.35
ORAI2 Q96SN7 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12169133 0.81 CHRNA7 (0.33) CHRNA7ACHETDP1ALDH1A1SMN1; SMN2
SCHEMBL28186864 0.81 CHRNA7 (0.33) CHRNA7ACHETDP1ALDH1A1SMN1; SMN2
SCHEMBL7199129 0.80 CHRNA7 (0.39) CHRNA7ACHETDP1ALDH1A1SMN1; SMN2
SCHEMBL1200882 0.80 TSHR (0.60) CHRNA7ACHETDP1ALDH1A1SMN1; SMN2
SCHEMBL8943828 0.80 ALDH1A1 (0.41) CHRNA7ACHETDP1ALDH1A1SMN1; SMN2
SCHEMBL3991740 0.80 TSHR (0.60) CHRNA7ACHETDP1ALDH1A1SMN1; SMN2
SCHEMBL2686081 0.80 VCP (0.46) ALDH1A1SMN1; SMN2FFAR1CACNA2D1CACNB2
SCHEMBL20865650 0.77 ACHE (0.45) ACHETDP1ALDH1A1SMN1; SMN2ALOX5
SCHEMBL8210082 0.76 ACHE (0.44) CHRNA7ACHETDP1ALDH1A1ALOX5
SCHEMBL10863597 0.75 ALDH1A1 (0.33) ACHEALDH1A1SMN1; SMN2FFAR1ALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1993022259-A1 A PROCESS FOR PRODUCING 1,4-BISARYL-BUTANE-1,4-DIONES AND POLY(ARYLENE-BUTANE-1,4-DIONES) NKT RESEARCH CENTER A/S (DK) 1993-11-11 WO disclosed