Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9724440 | 0.87 | GAA (0.64) | GAALMNACYP3A4SMN1; SMN2STAT3 | |
| SCHEMBL9724381 | 0.86 | GAA (0.46) | GAALMNASMN1; SMN2STAT3ALDH1A1 | |
| SCHEMBL187562 | 0.81 | LMNA (0.61) | GAALMNACYP3A4SMN1; SMN2ALDH1A1 | |
| SCHEMBL29354607 | 0.81 | LMNA (0.61) | GAALMNACYP3A4SMN1; SMN2ALDH1A1 | |
| SCHEMBL12284612 | 0.81 | GAA (0.42) | GAALMNACYP3A4SMN1; SMN2ALDH1A1 | |
| SCHEMBL28561801 | 0.80 | LMNA (0.59) | GAALMNACYP3A4SMN1; SMN2ALDH1A1 | |
| SCHEMBL4082027 | 0.78 | GAA (0.51) | GAALMNACYP3A4SMN1; SMN2ALDH1A1 | |
| SCHEMBL30388881 | 0.78 | GAA (0.75) | GAALMNACYP3A4ALDH1A1TDP1 | |
| SCHEMBL18255551 | 0.78 | GAA (0.75) | GAALMNACYP3A4ALDH1A1TDP1 | |
| SCHEMBL2405481 | 0.78 | CCR5 (0.52) | GAALMNAALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5198587-A | Adrenergic Blocking Agents, Hypotensive Agents | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1993-03-30 | — | — | US | disclosed |
| US-5063246-A | Hypotensive | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1991-11-05 | — | — | US | disclosed |
| US-4880841-A | ADRENERGIC BLOCKING AGENTS, HYPOTENSIVE AGENTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1989-11-14 | — | — | US | disclosed |