SCHEMBL9548255

SCHEMBL9548255

COc1cc(N)ccc1N.Cc1ccc(N)cc1N

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CASP1 P29466 2/20 0.65
ALDH1A1 P00352 10/20 0.53
CYP3A4 P08684 5/20 0.53
TSHR P16473 3/20 0.53
TDP1 Q9NUW8 3/20 0.53
HSD17B10 Q99714 1/20 0.53
MAPT P10636 3/20 0.48
GAA P10253 2/20 0.48
HTT P42858 2/20 0.48
MAPK1 P28482 1/20 0.48
NR4A1 P22736 1/20 0.47
TUBB4A P04350 1/20 0.46
TUBB P07437 1/20 0.46
TUBA3C P0DPH7 1/20 0.46
TUBA1B P68363 1/20 0.46
TUBA4A P68366 1/20 0.46
TUBB4B P68371 1/20 0.46
TUBB3 Q13509 1/20 0.46
TUBB2A Q13885 1/20 0.46
TUBB8 Q3ZCM7 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29375147 0.88 ALDH1A1 (0.67) ALDH1A1CYP3A4TSHRTDP1HSD17B10
SCHEMBL64099 0.88 ALDH1A1 (0.67) ALDH1A1CYP3A4TSHRTDP1HSD17B10
SCHEMBL9161948 0.86 ALDH1A1 (0.55) CASP1ALDH1A1CYP3A4TSHRTDP1
Hydrochloric Acid SCHEMBL10782973 0.86 ALDH1A1 (0.65) ALDH1A1CYP3A4TSHRTDP1HSD17B10
Hydrochloric Acid SCHEMBL10782376 0.86 ALDH1A1 (0.65) ALDH1A1CYP3A4TSHRTDP1HSD17B10
SCHEMBL264325 0.81 MAPT (0.57) CASP1ALDH1A1CYP3A4TSHRTDP1
SCHEMBL29354063 0.81
SCHEMBL5956120 0.81 CASP1 (1.00) CASP1ALDH1A1CYP3A4TSHRTDP1
SCHEMBL15010 0.81
Hydrochloric Acid SCHEMBL7132403 0.79 CASP1 (0.94) CASP1ALDH1A1CYP3A4TSHRTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5231172-A Water solubility HOECHST AKTIENGESELLSCHAFT (DE) 1993-07-27 US disclosed