Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | CPA1 | P15085 | 3/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.38 |
| ▸ | ARG1 | P05089 | 1/20 | 0.37 |
| ▸ | ARG2 | P78540 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | FDPS | P14324 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28145123 | 0.83 | HIF1A (0.44) | SMN1; SMN2HIF1AALDH1A1MMP8CES2 | |
| SCHEMBL10717351 | 0.79 | SMN1; SMN2 (0.50) | SMN1; SMN2HIF1ACES2CES1CPA1 | |
| SCHEMBL4155115 | 0.78 | TSHR (0.35) | HIF1AALDH1A1 | |
| SCHEMBL9617912 | 0.75 | SMN1; SMN2 (0.50) | SMN1; SMN2HIF1ARECQLCES2CES1 | |
| SCHEMBL11215729 | 0.74 | CES1 (0.40) | HIF1AALDH1A1CES2CES1 | |
| SCHEMBL27435752 | 0.73 | ALDH1A1 (0.54) | SMN1; SMN2ALDH1A1RECQLMMP8CYP2C19 | |
| SCHEMBL3270164 | 0.73 | PPARA (0.55) | SMN1; SMN2HIF1AALDH1A1RECQLMMP8 | |
| SCHEMBL28360703 | 0.72 | SMN1; SMN2 (0.47) | SMN1; SMN2HIF1ACES2CES1CPA1 | |
| SCHEMBL4362988 | 0.72 | SMN1; SMN2 (0.56) | SMN1; SMN2HIF1ARECQLCES2CES1 | |
| SCHEMBL14935688 | 0.72 | SMN1; SMN2 (0.56) | SMN1; SMN2HIF1ARECQLCES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5273989-A | 3,5-disubstituted 2-isoxazolines and isoxazoles, agents containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-12-28 | — | — | US | disclosed |