Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.40 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | ACP3 | P15309 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11451576 | 0.85 | HKDC1 (0.39) | OPRM1LMNASLC6A2SLC6A3 | |
| SCHEMBL6527714 | 0.82 | OPRM1 (0.48) | AOC3OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL7786059 | 0.82 | ACP3 (0.44) | AOC3PNMTACP3LMNATSHR | |
| SCHEMBL7102888 | 0.82 | ACP3 (0.41) | AOC3PNMTACP3LMNATSHR | |
| SCHEMBL8130729 | 0.82 | ACP3 (0.44) | AOC3PNMTACP3LMNATSHR | |
| SCHEMBL8779761 | 0.82 | ACP3 (0.44) | AOC3PNMTACP3LMNATSHR | |
| SCHEMBL10606192 | 0.80 | ACP3 (0.43) | AOC3OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL16771227 | 0.79 | ACP3 (0.46) | AOC3OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL12735693 | 0.79 | AOC3 (0.45) | AOC3OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL5724818 | 0.79 | TSHR (0.38) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2617706-B1 | NOVEL INTERMEDIATE USED FOR PREPARING TAPENTADOL OR ANALOGUES THEREOF | ANHUI NEW STAR PHARMACEUTICAL DEV CO LTD (CN) | 2017-09-06 | — | — | EP | disclosed |
| US-9682918-B2 | intermediate used for preparing tapentadol or analogues thereof | ANHUI NEW STAR PHARMACEUTICAL DEVLOPMENT CO., LTD. (CN) | 2017-06-20 | — | — | US | disclosed |
| US-9556107-B2 | Intermediate used for preparing tapentadol or analogues thereof | ANHUI NEW STAR PHARMACEUTICAL DEVELOPMENT CO., LTD. (CN) | 2017-01-31 | — | — | US | disclosed |
| US-20160052873-A1 | Novel Intermediate Used for Preparing Tapentadol or Analogues Thereof | ANHUI NEW STAR PHARMACEUTICAL DEVELOPMENT CO., LTD. (CN) | 2016-02-25 | — | — | US | disclosed |
| US-20160052866-A1 | Novel Intermediate Used for Preparing Tapentadol or Analogues Thereof | ANHUI NEW STAR PHARMACEUTICAL DEVELOPMENT CO., LTD. (CN) | 2016-02-25 | — | — | US | disclosed |
| US-8853393-B2 | Intermediate for preparing tapentadol or analogues thereof | ANHUI NEW STAR PHARMACEUTICAL DEVELOPMENT CO., LTD. (CN) | 2014-10-07 | — | — | US | disclosed |
| US-20130231478-A1 | Novel Intermediate for Preparing Tapentadol or Analogues Thereof | ANHUI NEW STAR PHARMACEUTICAL DEVELOPMENT CO., LTD. (CN) | 2013-09-05 | — | — | US | disclosed |
| EP-2617706-A1 | NOVEL INTERMEDIATE USED FOR PREPARING TAPENTADOL OR ANALOGUES THEREOF | Anhui New Star Pharmaceutical Development Co., Ltd (CN) | 2013-07-24 | — | — | EP | disclosed |
| US-7875645-B2 | 2-(2-cyclopropyl-benzyl)-4,5-dihydro-1H-imidazole; depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders | HOFFMAN-LA ROCHE INC. (US) | 2011-01-25 | — | — | US | disclosed |
| EP-1501804-B1 | ISOQUINOLINE DERIVATIVES MAO-B INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-08-26 | — | — | EP | disclosed |
| US-5232916-A | Inhibitors of leukotriene synthesis | MERCK FROSST CANADA, INC. (CA) | 1993-08-03 | — | — | US | disclosed |
| US-5102881-A | Leukotriene biosynthesis inhibitor | MERCK FROSST CANADA, INC. (CA) | 1992-04-07 | — | — | US | disclosed |
| US-4626549-A | Treatment of obesity with aryloxyphenylpropylamines | ELI LILLY AND COMPANY (US) | 1986-12-02 | — | — | US | disclosed |
| US-4313896-A | ANTIDEPRESSANTS, PSYCHOTROPIC AGENTS | ELI LILLY AND COMPANY (US) | 1982-02-02 | — | — | US | disclosed |
| US-4314081-A | ANTIDEPRESSANTS | ELI LILLY AND COMPANY (US) | 1982-02-02 | — | — | US | disclosed |
| EP-0004447-B1 | PREPARATION OF TRIFLUOROMETHYLPHENOLS AND NOVEL TRIFLUOROMETHYLPHENYL BENZYL ETHER INTERMEDIATES | ELI LILLY AND COMPANY (US) | 1981-12-02 | — | — | EP | disclosed |
| US-4210610-A | CHLOROARYLHYDROXY SUBSTITUTED ACETYLENES | GULF RESEARCH AND DEVELOPMENT COMPANY (US) | 1980-07-01 | — | — | US | disclosed |
| US-4194009-A | ANTIDEPRESSANT | ELI LILLY AND COMPANY (US) | 1980-03-18 | — | — | US | disclosed |
| US-4168388-A | Trifluoromethylphenyl benzyl ethers | ELI LILLY AND COMPANY (US) | 1979-09-18 | — | — | US | disclosed |
| US-4018895-A | Aryloxyphenylpropylamines in treating depression | ELI LILLY AND COMPANY (US) | 1977-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160052873-A1 | Novel Intermediate Used for Preparing Tapentadol or Analogues Thereof | CYP1A2, CYP7A1, ACHE | AOC3 1274/4885OPRM1 42/4885OPRD1 4/4885 |
| US-20130231478-A1 | Novel Intermediate for Preparing Tapentadol or Analogues Thereof | CYP1A2, CYP7A1, CYP3A5 | AOC3 1287/4885OPRM1 44/4885OPRD1 4/4885 |
| US-20160052866-A1 | Novel Intermediate Used for Preparing Tapentadol or Analogues Thereof | CYP1A2, CYP7A1, ACHE | AOC3 1274/4885OPRM1 42/4885OPRD1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.