Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.33 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1282584 | 0.86 | CYP2C19 (0.38) | PTPN1ALDH1A1CES2CES1HSD17B10 | |
| SCHEMBL8181122 | 0.84 | AKR1B1 (0.41) | PTPN1ALDH1A1ALOX15TDP1POLB | |
| SCHEMBL5665316 | 0.76 | AKR1B1 (0.48) | PTPN1ALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL5546711 | 0.76 | SLC9A1 (0.40) | PTPN1ALDH1A1KDM4EHSD17B10CASP6 | |
| SCHEMBL2095737 | 0.74 | KDM4E (0.37) | PTPN1ALDH1A1KDM4EHSD17B10CASP6 | |
| SCHEMBL21767386 | 0.71 | OPRM1 (0.43) | ALDH1A1KDM4EHSD17B10MEN1ALOX15 | |
| SCHEMBL4141035 | 0.71 | PTPN1 (0.51) | PTPN1ALDH1A1KDM4EHSD17B10MEN1 | |
| SCHEMBL2094790 | 0.71 | ALDH1A1 (0.34) | PTPN1ALDH1A1KDM4EHSD17B10CASP6 | |
| SCHEMBL2096586 | 0.70 | MAPT (0.34) | PTPN1ALDH1A1KDM4EHSD17B10CASP6 | |
| SCHEMBL1496470 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-5194465-A | — | — | None | — | — | JP | disclosed |
| JP-H05194465-A | 2-AMINO-MONO-METHOXYCYCLOHEXYLAMIDES USEFUL AS ANALGESIC | WARNER LAMBERT CO | 1993-08-03 | — | — | JP | disclosed |
| EP-0552386-A1 | 2-Amino-3 or 6-methoxycyclohexyl amide derivatives | WARNER-LAMBERT COMPANY (US) | 1993-07-28 | — | — | EP | disclosed |
| US-5051428-A | 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics | WARNER-LAMBERT COMPANY (US) | 1991-09-24 | — | — | US | disclosed |
| EP-0372466-A2 | 2-Amino-4 or 5-methoxycyclohexyl amides useful as analgesics | WARNER-LAMBERT COMPANY (US) | 1990-06-13 | — | — | EP | disclosed |