Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 1/20 | 0.35 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.35 |
| ▸ | P4HB | P07237 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | GMNN | O75496 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CA3 | P07451 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9550729 | 0.73 | SMN1; SMN2 (0.33) | ALDH1A1LMNAPOLBMAPTHPGD | |
| SCHEMBL9198984 | 0.67 | GABRA1 (0.41) | P4HBALOX15KDM4ENPC1CA12 | |
| SCHEMBL9198990 | 0.66 | GABRA1 (0.44) | P4HBALOX15KDM4ENPC1CA12 | |
| SCHEMBL79176 | 0.66 | GABRA1 (0.44) | P4HBALOX15KDM4ENPC1CA12 | |
| Formaldehyde SCHEMBL11203204 | 0.65 | HPGD (0.45) | TRIM24TRIM33P4HBALOX15KDM4E | |
| SCHEMBL3803606 | 0.64 | GABRA1 (0.43) | TRIM24TRIM33CDK4CCND1ALOX15 | |
| SCHEMBL10568195 | 0.63 | ALOX15 (0.38) | TRIM24TRIM33P4HBALOX15KDM4E | |
| SCHEMBL8844526 | 0.63 | EPHX2 (0.45) | TRIM24TRIM33P4HBCDK4CCND1 | |
| SCHEMBL8464396 | 0.62 | — | — | |
| SCHEMBL79979 | 0.62 | MEN1 (0.41) | P4HBALOX15KDM4ENPC1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0339688-B1 | HYDROXYPHENYLTHIOALKYLKETONES | G.D. Searle & Co. (US) | 1993-03-10 | — | — | EP | disclosed |
| EP-0339688-A1 | Hydroxyphenylthioalkylketones | G.D. Searle & Co. (US) | 1989-11-02 | — | — | EP | disclosed |