Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9550728 | 0.73 | TRIM24 (0.35) | SMN1; SMN2LMNAMAPTHPGDHSD17B10 | |
| SCHEMBL7184387 | 0.73 | SMN1; SMN2 (0.39) | SMN1; SMN2LMNAMAPTHPGDMGLL | |
| SCHEMBL809567 | 0.70 | LMNA (0.39) | SMN1; SMN2LMNAMAPTHPGDMGLL | |
| SCHEMBL28694462 | 0.70 | MAOA (0.38) | SMN1; SMN2LMNAMAPTHPGDMGLL | |
| SCHEMBL7581178 | 0.70 | MAOA (0.38) | SMN1; SMN2LMNAMAPTHPGDMGLL | |
| SCHEMBL9331396 | 0.70 | MAPT (0.36) | SMN1; SMN2LMNAMAPTHPGDMGLL | |
| SCHEMBL10345825 | 0.70 | ALDH1A1 (0.39) | SMN1; SMN2LMNAMAPTHPGDMGLL | |
| SCHEMBL15068448 | 0.70 | MAPT (0.36) | SMN1; SMN2LMNAMAPTHPGDMGLL | |
| SCHEMBL23964577 | 0.67 | SMN1; SMN2 (0.38) | SMN1; SMN2LMNAMAPTHPGDMGLL | |
| SCHEMBL809548 | 0.67 | LMNA (0.37) | SMN1; SMN2LMNAMAPTHPGDMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5229421-A | Antiallergens, antiinflammatory agents | G. D. SEARLE & CO. (US) | 1993-07-20 | — | — | US | disclosed |
| US-5208262-A | Administering 4-hydroxythiophenol derivatives | G. D. SEARLE & CO. (US) | 1993-05-04 | — | — | US | disclosed |
| EP-0339688-B1 | HYDROXYPHENYLTHIOALKYLKETONES | G.D. Searle & Co. (US) | 1993-03-10 | — | — | EP | disclosed |
| US-5047593-A | Antiinflammatory And Antiallergy Agents | G. D. SEARLE & CO. (US) | 1991-09-10 | — | — | US | disclosed |
| EP-0339688-A1 | Hydroxyphenylthioalkylketones | G.D. Searle & Co. (US) | 1989-11-02 | — | — | EP | disclosed |
| US-4857558-A | ANTIINFLAMMATORY AGENTS AND-OR ANTIALLERGENS | G. D. SEARLE & CO. (US) | 1989-08-15 | — | — | US | disclosed |
| EP-0218782-A1 | Lipoxygenase-inhibiting composition and hydroxyphenylthioalkylcarbonyl compounds | G.D. Searle & Co. (US) | 1987-04-22 | — | — | EP | disclosed |